Lower urinary tract symptoms in patients with small prostates: Smooth muscle proliferation and calcification might be causative factors.

IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY LUTS: Lower Urinary Tract Symptoms Pub Date : 2022-07-01 Epub Date: 2022-02-17 DOI:10.1111/luts.12432
Muhammad Muneeb Ather, Sadia Aman, Huma Qamar, Rabia Latif, Muhammad Bahadur Baloch, Uruj Zehra
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引用次数: 1

Abstract

Objectives: The current study is designed to evaluate and compare the histological changes in the surgical samples of prostate taken from patients undergoing transurethral resection of prostate (TURP) for benign prostate hyperplasia (BPH) with different sizes.

Methods: Prostate surgical tissue samples were obtained from BPH patients undergoing TURP after taking informed consent. Ultrasound measure of prostatic weight and prostate-specific antigen (PSA) levels were obtained from the patients along with other clinical and demographic details. Tissue samples were fixed, processed, sectioned and stained with hematoxylin and eosin and Masson's trichrome to look for histological features, specifically smooth muscle proliferation. Immunohistochemical expression of bone morphogenetic protein (BMP)-2 was recorded to assess the calcification potential.

Results: Fifty-nine surgical samples were obtained from the patients of age range 50-90 years and body mass index (BMI) 15.6-33.3 kg/m2 . The range of ultrasound measures of prostate weight was 20-137 g with PSA ranged 1.03-93.3 ng/mL. Patients with small-sized prostate had significant severe smooth muscle proliferation (P < .001). Prostate size/weight had significant positive association with BMI (P < 0.001, r = 0.543) and negative association with BMP-2 (P < 0.001, r = -0.654). Samples with severe smooth muscle proliferation were with increased BMP-2 expression (P < .001) and higher levels of PSA levels (P = 0.004). BMP-2 expression revealed positive significant association with PSA (P < .001, r = 0.432).

Conclusion: From this study we conclude that BPH patients with small-sized glands and high PSA levels have increased smooth muscle proliferation and calcification potential causing the symptoms of lower urinary tract symptoms in these patients.

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小前列腺患者的下尿路症状:平滑肌增生和钙化可能是病因。
目的:本研究旨在评价和比较经尿道前列腺切除术(TURP)治疗不同大小良性前列腺增生(BPH)患者的前列腺手术标本的组织学变化。方法:在知情同意后,从行TURP的BPH患者中获取前列腺手术组织样本。超声测量患者的前列腺重量和前列腺特异性抗原(PSA)水平以及其他临床和人口统计学细节。将组织样本固定、处理、切片,并用苏木精、伊红和马松三色染色来寻找组织学特征,特别是平滑肌增生。记录骨形态发生蛋白(BMP)-2的免疫组织化学表达以评估钙化电位。结果:手术样本59份,年龄50 ~ 90岁,体重指数(BMI) 15.6 ~ 33.3 kg/m2。超声测量前列腺重量范围20 ~ 137 g, PSA范围1.03 ~ 93.3 ng/mL。结论:本研究提示前列腺体积小且PSA水平高的BPH患者平滑肌增生和钙化电位增高,导致患者出现下尿路症状。
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来源期刊
LUTS: Lower Urinary Tract Symptoms
LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-
CiteScore
3.00
自引率
7.70%
发文量
52
审稿时长
>12 weeks
期刊介绍: LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.
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