Optical Coherence Tomography Prognostic Factors in Age-Related Macular Degeneration Patients with Peripapillary Choroidal Neovascularization.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY Ophthalmologica Pub Date : 2022-01-01 Epub Date: 2021-11-22 DOI:10.1159/000520930

Gilad Rabina, Anfisa Ayalon, Michael Mimouni, Nir Stanescu, Elad Moisseiev, Arie Y Nemet, Noa Geffen, Ori Segal

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Abstract

Purpose: The aim of the study was to investigate the correlation between optical coherence tomography (OCT) findings and visual acuity outcomes after treatment with intravitreal bevacizumab (IVB) injections for age-related macular degeneration (AMD) patients with peripapillary choroidal neovascularization (PPCNV).

Methods: The study involved a retrospective case series of consecutive patients diagnosed with PPCNV secondary to AMD. All patients were treated with IVB injections with a follow-up time of 1 year. Data collected included best-corrected visual acuity (BCVA) and automated and manually measured OCT parameters.

Results: A total of 68 eyes were diagnosed with PPMV. Of them, 30 eyes of 30 patients aged 84.3 ± 6.9 years of which 63.3% female gender were included. Baseline BCVA was 0.46 ± 0.62 logMAR (Snellen 20/57), average choroidal thickness was 193.2 ± 22 μm, and mean number of IVB injections was 7.2 ± 1.9. After 1 year, BCVA was 0.56 ± 0.78 logMAR (Snellen 20/72) (p = 0.28). Eyes with greater central retinal thickness (r = -0.36, p = 0.05), greater subretinal hyper-reflective material (SHRM) area (r = -0.37, p = 0.05), and greater sub-retinal fluid (SRF) area (r = -0.73, p < 0.001) had a significantly smaller improvement in BCVA. Eyes with pigment epithelium detachment (PED) (0.68 ± 0.90 vs. 0.21 ± 0.12, p = 0.03) had a significantly worse BCVA.

Conclusions: Our data suggest that AMD-related PPCNV with greater foveal thickness, PED size, SHRM, and SRF areas have worse final BCVA prognosis.

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年龄相关性黄斑变性伴乳突周围脉络膜新生血管患者的光学相干断层成像预后因素。

目的:研究贝伐单抗(IVB)玻璃体内注射治疗年龄相关性黄斑变性(AMD)伴乳头周围脉络膜新生血管(PPCNV)患者后光学相干断层扫描(OCT)结果与视力结果的相关性。方法:研究纳入了连续诊断为继发于AMD的PPCNV患者的回顾性病例系列。所有患者均接受静脉注射治疗，随访1年。收集的数据包括最佳矫正视力(BCVA)和自动和手动测量的OCT参数。结果:68只眼被诊断为PPMV。其中30例患者30眼，年龄84.3±6.9岁，女性63.3%。基线BCVA为0.46±0.62 logMAR (Snellen 20/57)，平均脉络膜厚度为193.2±22 μm，平均IVB注射次数为7.2±1.9次。1年后，BCVA为0.56±0.78 logMAR (Snellen 20/72) (p = 0.28)。视网膜中央厚度较大(r = -0.36, p = 0.05)、视网膜下超反射物质(SHRM)面积较大(r = -0.37, p = 0.05)和视网膜下液体(SRF)面积较大(r = -0.73, p < 0.001)的眼BCVA改善程度较小。色素上皮脱离(PED)组(0.68±0.90 vs. 0.21±0.12,p = 0.03)的BCVA明显较差。结论:我们的数据表明，amd相关的PPCNV具有较大的中央凹厚度、PED大小、SHRM和SRF区域，最终BCVA预后较差。

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来源期刊

Ophthalmologica 医学-眼科学

CiteScore

5.10

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.