Psoriasis and 5HT-R2C Gene Polymorphism: Association between Clinical, Demographic and Therapeutic Parameters in the Turkish Population.

IF 0.6 4区 医学 Q4 DERMATOLOGY Acta Dermatovenerologica Croatica Pub Date : 2021-12-01
Sehime G Temel, Serkan Yazici, İzel Yilmaz, Özgür Tosun, Mahmut Cerkez Ergoren, Emel Bulbul Baskan, Barbaros Oral, Kenan Aydogan
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Abstract

We aimed to investigate the relationship between single nucleotide polymorphism (SNP) in the promoter region of the 5-HT-R2C gene and stress-related disease psoriasis in the Turkish population. The putative association between the 5-HTR2C variant (rs6318 Cys23Ser allele) and patients with psoriasis was investigated. 100 patients with psoriasis and 100 age-sex matched, unrelated healthy subjects representing the control group were included in the study. The PCR-RFLP method was used for genotyping the 5-HTR2C variation. There was no statistically difference in terms of genotype distributions and allele frequencies between the control subjects and patients with psoriasis (P=0.360 and P=0.439, respectively). The comparison between the presence and absence of the 5-HTR2C gene rs6318 G allele within the determined clinical subsets resulted in a significant difference with regard to treatment methodology only when conventional therapy and one or more medical therapy was compared (P=0.021). This study is the first clinical study to investigate the association between 5-HTR2C polymorphism and psoriasis. The role of the 5-HTR2C gene should be examined with more parameters in a larger case series.

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牛皮癣和5HT-R2C基因多态性:土耳其人群临床、人口统计学和治疗参数之间的关系
我们旨在研究土耳其人群中5-HT-R2C基因启动子区域的单核苷酸多态性(SNP)与应激相关疾病牛皮癣之间的关系。研究了5-HTR2C变异(rs6318 Cys23Ser等位基因)与牛皮癣患者之间的推定关联。研究包括100名牛皮癣患者和100名年龄性别匹配、不相关的健康受试者作为对照组。采用PCR-RFLP方法对5-HTR2C变异进行基因分型。对照组与银屑病患者的基因型分布、等位基因频率差异无统计学意义(P=0.360、P=0.439)。在确定的临床亚群中比较5-HTR2C基因rs6318 G等位基因的存在与缺失,只有在比较常规治疗和一种或多种药物治疗时,才会在治疗方法上产生显著差异(P=0.021)。本研究是首个探讨5-HTR2C多态性与银屑病之间关系的临床研究。5-HTR2C基因的作用应该在更大的病例序列中用更多的参数来检验。
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来源期刊
Acta Dermatovenerologica Croatica
Acta Dermatovenerologica Croatica 医学-皮肤病学
CiteScore
0.60
自引率
0.00%
发文量
23
审稿时长
>12 weeks
期刊介绍: Acta Dermatovenerologica Croatica (ADC) aims to provide dermatovenerologists with up-to-date information on all aspects of the diagnosis and management of skin and venereal diseases. Accepted articles regularly include original scientific articles, short scientific communications, clinical articles, case reports, reviews, reports, news and correspondence. ADC is guided by a distinguished, international editorial board and encourages approach to continuing medical education for dermatovenerologists.
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