MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury

Comparative and Functional Genomics Pub Date : 2021-11-20 DOI:10.1155/2021/9098145

Mingming Cao, Wenjing Song, Runyu Liang, Lili Teng, Mei Zhang, Jiyao Zhang, Luwen Zhu

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Abstract

Ischemia-reperfusion (I/R) injury is a progressive injury that aggravates the pathological state when the organ tissue restores blood supply after a certain period of ischemia, including the myocardial, brain, liver, kidney, and intestinal. With growing evidence that microRNAs (miRNAs) play an important role as posttranscription gene silencing mediators in many I/R injury, in this review, we highlight the microRNAs that are related to I/R injury and their regulatory molecular pathways. In addition, we discussed the potential role of miRNA as a biomarker and its role as a target in I/R injury treatment. Developing miRNAs are not without its challenges, but prudent design combined with existing clinical treatments will result in more effective therapies for I/R injury. This review is aimed at providing new research results obtained in this research field. It is hoped that new research on this topic will not only generate new insights into the pathophysiology of miRNA in I/R injury but also can provide a basis for the clinical application of miRNA in I/R.

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MicroRNA作为缺血再灌注损伤的潜在生物标志物和治疗策略

缺血再灌注（I/R）损伤是指心肌、脑、肝、肾、肠等器官组织在缺血一定时期后恢复血液供应，使病理状态加重的进行性损伤。随着越来越多的证据表明microRNAs （miRNAs）在许多I/R损伤中作为转录后基因沉默介质发挥重要作用，在本文中，我们重点介绍了与I/R损伤相关的microRNAs及其调控分子途径。此外，我们还讨论了miRNA作为生物标志物的潜在作用及其在I/R损伤治疗中的作用。开发mirna并非没有挑战，但谨慎的设计结合现有的临床治疗方法将使I/R损伤的治疗更有效。本文旨在介绍这一研究领域的最新研究成果。希望本课题的新研究不仅能对miRNA在I/R损伤中的病理生理有新的认识，也能为miRNA在I/R中的临床应用提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comparative and Functional Genomics 生物-生化与分子生物学

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2 months