Navin B Ramakrishna, Keir Murison, Eric A Miska, Harry G Leitch
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引用次数: 0
Abstract
Germline development varies significantly across metazoans. However, mammalian primordial germ cell (PGC) development has key conserved landmarks, including a critical period of epigenetic reprogramming that precedes sex-specific differentiation and gametogenesis. Epigenetic alterations in the germline are of unique importance due to their potential to impact the next generation. Therefore, regulation of, and by, the non-coding genome is of utmost importance during these epigenomic events. Here, we detail the key chromatin changes that occur during mammalian PGC development and how these interact with the expression of non-coding RNAs alongside broader epitranscriptomic changes. We identify gaps in our current knowledge, in particular regarding epigenetic regulation in the human germline, and we highlight important areas of future research.
元古动物的生殖细胞发育差异很大。然而，哺乳动物的原始生殖细胞（PGC）发育具有关键的保守标志，包括在性别特异性分化和配子发生之前的表观遗传重编程关键时期。生殖细胞中的表观遗传改变具有独特的重要性，因为它们有可能影响下一代。因此，在这些表观基因组事件中，非编码基因组的调控至关重要。在这里，我们详细介绍了哺乳动物 PGC 发育过程中发生的关键染色质变化，以及这些变化如何与非编码 RNA 的表达以及更广泛的表观转录组变化相互作用。我们找出了目前知识中的空白，特别是有关人类生殖系表观遗传调控的知识，并强调了未来研究的重要领域。
期刊介绍：
Recent discoveries in experimental and clinical research have led to impressive advances in our knowledge of the genetic and environmental mechanisms governing sex determination and differentiation, their evolution as well as the mutations or endocrine and metabolic abnormalities that interfere with normal gonadal development. ‘Sexual Development’ provides a unique forum for this rapidly expanding field. Its broad scope covers all aspects of genetics, molecular biology, embryology, endocrinology, evolution and pathology of sex determination and differentiation in humans and animals. It publishes high-quality original research manuscripts, review articles, short reports, case reports and commentaries. An internationally renowned and multidisciplinary editorial team of three chief editors, ten prominent scientists serving as section editors, and a distinguished panel of editorial board members ensures fast and author-friendly editorial processing and peer reviewing.
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