Local Antibiotic Delivery Systems in Diabetic Foot Osteomyelitis: A Brief Review.

Q3 Medicine Review of Diabetic Studies Pub Date : 2021-11-01 DOI:10.1900/RDS.2021.17.75

Christos Chatzipapas, Makrina Karaglani, Nikolaos Papanas, Konstantinos Tilkeridis, Georgios I Drosos

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引用次数: 1

Abstract

Diabetic foot osteomyelitis (DFO) is a severe, difficult to treat infection. Local antibiotic delivery has been studied as a potential therapeutic adjunct following surgery for DFO. This review aims to summarize the evidence on local antibiotic delivery systems in DFO. PubMed database was searched up to March 2020. Overall, 16 studies were identified and included: 3 randomized controlled trials (RCTs), 3 retrospective studies (RSs), and 10 case series. In the RCTs, gentamicin-impregnated collagen sponges significantly improved clinical healing rates and slightly improved duration of hospitalization. In the RSs, antibiotic-impregnated calcium sulfate beads non-significantly improved all healing parameters, but did not reduce post-operative amputation rates or time of healing. The majority of case series used calcium sulfate beads, achieving adequate rates of healing and eradication of infection. In conclusion, evidence for add-on local antibiotic delivery in DFO is still limited; more data are needed to assess this therapeutic measure.

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糖尿病足骨髓炎的局部抗生素递送系统:简要综述。

糖尿病足骨髓炎(DFO)是一种严重的、难以治疗的感染。局部抗生素递送已被研究作为DFO手术后潜在的治疗辅助手段。本文综述了DFO局部抗生素给药系统的相关证据。PubMed数据库检索截止到2020年3月。共纳入16项研究:3项随机对照试验(rct)、3项回顾性研究(RSs)和10个病例系列。在随机对照试验中，庆大霉素浸渍的胶原海绵显著提高了临床治愈率，并略微改善了住院时间。在RSs中，抗生素浸渍硫酸钙珠无显著改善所有愈合参数，但没有减少术后截肢率或愈合时间。大多数病例系列使用硫酸钙珠，达到足够的愈合率和根除感染。总之，在DFO中添加局部抗生素的证据仍然有限;需要更多的数据来评估这种治疗措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Review of Diabetic Studies Medicine-Internal Medicine

CiteScore

1.80

自引率

0.00%

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期刊介绍： The Review of Diabetic Studies (RDS) is the society"s peer-reviewed journal published quarterly. The purpose of The RDS is to support and encourage research in biomedical diabetes-related science including areas such as endocrinology, immunology, epidemiology, genetics, cell-based research, developmental research, bioengineering and disease management.