A COVINDEX based on a GAM beta regression model with an application to the COVID-19 pandemic in Italy.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-01-01 Epub Date: 2022-01-10 DOI:10.1007/s10260-021-00617-y
Luca Scrucca
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Abstract

Detecting changes in COVID-19 disease transmission over time is a key indicator of epidemic growth. Near real-time monitoring of the pandemic growth is crucial for policy makers and public health officials who need to make informed decisions about whether to enforce lockdowns or allow certain activities. The effective reproduction number R t is the standard index used in many countries for this goal. However, it is known that due to the delays between infection and case registration, its use for decision making is somewhat limited. In this paper a near real-time COVINDEX is proposed for monitoring the evolution of the pandemic. The index is computed from predictions obtained from a GAM beta regression for modelling the test positive rate as a function of time. The proposal is illustrated using data on COVID-19 pandemic in Italy and compared with R t . A simple chart is also proposed for monitoring local and national outbreaks by policy makers and public health officials.

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基于 GAM β 回归模型的 COVINDEX,应用于意大利的 COVID-19 大流行病。
检测 COVID-19 疾病传播随时间的变化是衡量流行病增长的一个关键指标。对疫情增长进行近乎实时的监测对决策者和公共卫生官员来说至关重要,他们需要在知情的情况下决定是否实施封锁或允许某些活动。有效繁殖数 R t 是许多国家用于实现这一目标的标准指数。然而,众所周知,由于感染和病例登记之间存在延迟,该指标在决策中的应用受到一定限制。本文提出了一种近乎实时的 COVINDEX,用于监测大流行病的演变。该指数是根据 GAM β 回归的预测结果计算得出的,GAM β 回归用于模拟检测阳性率与时间的函数关系。使用意大利 COVID-19 大流行的数据对该建议进行了说明,并与 R t 进行了比较。还提出了一个简单的图表,供决策者和公共卫生官员监测地方和国家疫情。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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