Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer's Disease.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2022-01-01 DOI:10.1177/15333175211070912

Kaushik Ravipati, Yunxiao Chen, Joseph R Manns

{"title":"Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer's Disease.","authors":"Kaushik Ravipati, Yunxiao Chen, Joseph R Manns","doi":"10.1177/15333175211070912","DOIUrl":null,"url":null,"abstract":"Objective: To assess whether diabetes alone or in association with Apolipoprotein E (APOE) ε4 genotype increases the risk of Alzheimer's Disease (AD) diagnosis. Methods: A retrospective cohort study of 33,456 participants from the National Alzheimer's Coordinating Center database. Results: Participants with one or two APOE ε4 alleles had 2.71 (CI:2.55-2.88) and 9.37 (CI:8.14-10.78) times higher odds of AD diagnosis, respectively, relative to those with zero ε4 alleles. In contrast, diabetic participants showed 1.07 (CI:0.96-1.18) times higher odds of AD relative to nondiabetics. Diabetes did not exacerbate the odds of AD in APOE ε4 carriers. APOE ε4 carriage was correlated with declines in long-term memory and verbal fluency, which were strongly correlated with conversion to AD. However, diabetes was correlated with working memory decline, which had a relatively weak correlation with AD. Conclusions: Unlike APOE ε4, there was little evidence that diabetes was a risk factor for AD.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"15333175211070912"},"PeriodicalIF":4.7000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10623968/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15333175211070912","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To assess whether diabetes alone or in association with Apolipoprotein E (APOE) ε4 genotype increases the risk of Alzheimer's Disease (AD) diagnosis. Methods: A retrospective cohort study of 33,456 participants from the National Alzheimer's Coordinating Center database. Results: Participants with one or two APOE ε4 alleles had 2.71 (CI:2.55-2.88) and 9.37 (CI:8.14-10.78) times higher odds of AD diagnosis, respectively, relative to those with zero ε4 alleles. In contrast, diabetic participants showed 1.07 (CI:0.96-1.18) times higher odds of AD relative to nondiabetics. Diabetes did not exacerbate the odds of AD in APOE ε4 carriers. APOE ε4 carriage was correlated with declines in long-term memory and verbal fluency, which were strongly correlated with conversion to AD. However, diabetes was correlated with working memory decline, which had a relatively weak correlation with AD. Conclusions: Unlike APOE ε4, there was little evidence that diabetes was a risk factor for AD.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

糖尿病和APOE基因型作为阿尔茨海默病潜在相互作用的危险因素的重新评估。

目的：评估糖尿病单独或与载脂蛋白Eε4基因型相关是否会增加阿尔茨海默病（AD）诊断的风险。方法：对来自国家阿尔茨海默病协调中心数据库的33456名参与者进行回顾性队列研究。结果：与ε4等位基因为零的参与者相比，具有一个或两个APOEε4等基因的参与者诊断AD的几率分别高2.71倍（CI:2.55-2.88）和9.37倍（CI:8.14-17.78）。相比之下，糖尿病参与者患AD的几率是非糖尿病参与者的1.07倍（CI：0.96-1.18）。糖尿病并没有增加APOEε4携带者患AD的几率。APOEε4的携带与长期记忆和语言流利度的下降相关，这与AD的转换密切相关。然而，糖尿病与工作记忆下降相关，工作记忆下降与AD的相关性相对较弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.