Stakeholders' Perspectives regarding Participation in Neuromodulation-Based Dementia Intervention Research.

IF 1.7 4区哲学 Q2 ETHICS Journal of Empirical Research on Human Research Ethics Pub Date : 2022-02-01 Epub Date: 2021-12-06 DOI:10.1177/15562646211060997

Laura B Dunn, Jane P Kim, Maryam Rostami, Sangeeta Mondal, Katie Ryan, Asees Waraich, Laura Weiss Roberts, Barton W Palmer

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引用次数: 2

Abstract

This study evaluated stakeholders' perspectives regarding participation in two hypothetical neuromodulation trials focused on individuals with Alzheimer's disease and related disorders (ADRDs). Stakeholders (i.e., individuals at risk for ADRDs [n = 56], individuals with experience as a caregiver for someone with a cognitive disorder [n = 60], and comparison respondents [n = 124]) were recruited via MTurk. Primary outcomes were willingness to enroll (or enroll one's loved one), feeling lucky to have the opportunity to enroll, and feeling obligated to enroll in two protocols (transcranial magnetic stimulation, TMS; deep brain stimulation, DBS). Relative to the Comparison group, the At Risk group endorsed higher levels of "feeling lucky" regarding both research protocols, and higher willingness to participate in the TMS protocol. These findings provide tentative reassurance regarding the nature of decision making regarding neurotechnology-based research on ADRDs. Further work is needed to evaluate the full range of potential influences on research participation.

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利益相关者对参与基于神经调节的痴呆干预研究的看法

这项研究评估了利益相关者对参与两项假设的神经调控试验的看法，这两项试验侧重于阿尔茨海默病和相关疾病（ADRD）患者。利益相关者（即有ADR风险的个人[n = 56]，有照顾认知障碍患者经验的人[n = 60]，以及比较受访者[n = 124]）通过MTurk招募。主要结果是愿意加入（或加入自己的爱人），有机会加入感到幸运，以及有义务加入两种方案（经颅磁刺激，TMS；深部脑刺激，DBS）。与对照组相比，风险组对两种研究方案的“幸运感”水平更高，参与TMS方案的意愿更高。这些发现为基于神经技术的ADR研究的决策性质提供了初步的保证。需要进一步的工作来评估对研究参与的所有潜在影响。

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来源期刊

Journal of Empirical Research on Human Research Ethics 医学-医学：伦理

CiteScore

3.50

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Empirical Research on Human Research Ethics (JERHRE) is the only journal in the field of human research ethics dedicated exclusively to empirical research. Empirical knowledge translates ethical principles into procedures appropriate to specific cultures, contexts, and research topics. The journal''s distinguished editorial and advisory board brings a range of expertise and international perspective to provide high-quality double-blind peer-reviewed original articles.