Better neuroprotective profile of caffeic acid phenyl ester over resveratrol in non-traumatic ischemia-reperfusion injury of the spinal cord.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2021-12-09 DOI:10.1080/02688697.2021.1999391

Esra Aslan, Mehmet Gazi Boyacı, Hilal Güzel, Mehmet Bilgehan Pektaş

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Abstract

Background: Spinal cord ischemia has serious sequelae. The aim of this study is to investigate the effects of resveratrol and caffeic acid phenyl ester (CAPE), a propolis derivative, on spinal cord injury induced by ischemia-reperfusion (IR).

Methods: In our research, 30 male Wistar albino rats, 200-250 gr, were used. Before the experiment, during a week of the process, the rats were fed with these two agents, and the experimental group rats were exposed to spinal cord IR injury. At the end of the experiment, spinal cord samples were taken from the sacrificed rats. Bax, p53, nNOS, and Beclin-1 immunoreactivity moreover TUNEL (+) cells were evaluated with immunohistochemically in the IR-induced damaged rats.

Results: It has been clearly determined that the TUNEL (+) apoptotic cell number and immunopositive cells of nNOS, Beclin-1, p53, Bax were raised in the IR group. However, these increments partially were restored in the resveratrol and CAPE-fed rats with IR-induced injury.

Conclusion: In light of our data, resveratrol, and CAPE could be beneficial in spinal cord IR injury. Although both agents provide beneficial effects, it can be said that CAPE is partially more effective in spinal cord injury caused by IR.

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在非创伤性脊髓缺血再灌注损伤中，咖啡酸苯酯比白藜芦醇具有更好的神经保护作用。

背景：脊髓缺血具有严重的后遗症。本研究旨在探讨白藜芦醇和蜂胶衍生物咖啡酸苯酯（CAPE）对缺血再灌注（IR）引起的脊髓损伤的影响：我们的研究使用了 30 只雄性 Wistar 白化大鼠（200-250 克）。实验前，在为期一周的过程中，给大鼠喂食这两种药剂，实验组大鼠受到脊髓 IR 损伤。实验结束后，从牺牲的大鼠身上提取脊髓样本。用免疫组化方法对红外损伤大鼠的 Bax、p53、nNOS 和 Beclin-1 免疫反应以及 TUNEL（+）细胞进行评估：结果：可以清楚地看出，在红外组中，TUNEL（+）凋亡细胞数量和 nNOS、Beclin-1、p53、Bax 的免疫阳性细胞数量都有所增加。结论：根据我们的数据，白藜芦醇和 CAPE 饲喂的红外诱导损伤大鼠的凋亡细胞数量和免疫阳性细胞数量均有所增加，但这些增量在白藜芦醇和 CAPE 饲喂的红外诱导损伤大鼠中得到了部分恢复：根据我们的数据，白藜芦醇和 CAPE 对脊髓红外损伤有益。结论：根据我们的数据，白藜芦醇和 CAPE 对红外损伤的脊髓都有益处。虽然两种药物都有益处，但可以说 CAPE 对红外损伤引起的脊髓损伤更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.