{"title":"THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA.","authors":"Phumelele Kikine, Yazira Pillay, Thajasvarie Naicker","doi":"10.1080/10641955.2021.2001819","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE.</p><p><strong>Methods: </strong>This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay.</p><p><strong>Results: </strong>A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed.</p><p><strong>Conclusion: </strong>Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"9-14"},"PeriodicalIF":1.5000,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hypertension in Pregnancy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10641955.2021.2001819","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/11/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE.
Methods: This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay.
Results: A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed.
Conclusion: Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.
期刊介绍：
Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.
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