Exploring Effects of Aerobic Exercise and Mindfulness Training on Cognitive Function in Older Adults at Risk of Dementia: A Feasibility, Proof-of-Concept Study.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2021-01-01 DOI:10.1177/15333175211039094

Elena Salmoirago-Blotcher, Dyuti Trivedi, Shira Dunsiger, Kristie Harris, Christopher Breault, Cláudia Yang Santos, Kristen Walaska, Peter Snyder, Ronald Cohen

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Abstract

Objectives: This study sought to explore feasibility, acceptability, and preliminary effects of aerobic training (AT), mindfulness training (MT), or both (MT + AT) on cognitive function in older individuals at risk of dementia.

Method: Participants were randomized to AT, MT, both, or usual care (UC). Z-scores of attention, verbal fluency, and episodic memory for non-demented adults (ZAVEN) were computed at baseline, end of treatment (EOT), and 6 months since baseline.

Results: Of the 36 enrolled participants (12 M, 24 F, mean age = 70.1 years), 97% were retained in the study at 6 months. At EOT, MT had higher ZAVEN scores than UC (b = .43, P =.03) and AT (b = .26, P = .10), while no differences were seen with MT + AT. A similar pattern was observed at a 6 month follow-up (all P values = .10).

Discussion: MT may improve cognitive function in older individuals at risk of dementia. These preliminary findings need to be confirmed in a fully powered RCT.

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探索有氧运动和正念训练对老年痴呆症高危人群认知功能的影响：可行性概念验证研究

研究目的：本研究旨在探讨有氧训练（AT）、正念训练（MT）或两者（MT + AT）的可行性、可接受性以及对老年痴呆症高危人群认知功能的初步影响：方法：参与者随机接受有氧训练、正念训练、两者或常规护理（UC）。在基线、治疗结束（EOT）和基线后 6 个月时计算非痴呆成人的注意力、语言流畅性和外显记忆（ZAVEN）的 Z 值：在 36 名参加者（12 名男性，24 名女性，平均年龄 70.1 岁）中，97% 的人在 6 个月后仍留在研究中。在EOT时，MT的ZAVEN评分高于UC（b = .43，P =.03）和AT（b = .26，P = .10），而MT + AT则无差异。在 6 个月的随访中也观察到类似的模式（所有 P 值 = .10）：讨论：MT 可改善有痴呆风险的老年人的认知功能。这些初步研究结果还需要在完全有效的 RCT 中得到证实。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.