Triglyceride glucose index reflects the unfavorable changes of left ventricular diastolic functions and structure in uncomplicated newly diagnosed hypertensive patients.
Sara Cetin Sanlialp, Musa Sanlialp, Gokay Nar, Aydan Malcok
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引用次数: 3
Abstract
Introduction: Left ventricular (LV) diastolic dysfunction and structural abnormalities are common cardiac changes in hypertension (HTN), and several factors other than high blood pressure (BP) may play a role in these changes. The aim of this study was to reveal the relationship between triglyceride glucose (TyG) index, a novel parameter for insulin resistance (IR), with LV diastolic function and structure in hypertensive patients.
Material and method: A total of 119 newly diagnosed, untrated hypertensive patients free of diabetes and/or cardiovascular complications were included in this study. IR was estimated with the TyG index calculated from ln [fasting TG (mg/dL) × fasting blood glucose (mg/dL)/2]. Two-dimensional and Doppler echocardiographic examinations were performed to assess LV diastolic functions and structure.
Results: Based on median TyG index, 51 patients was assigned as group I (<8.7) and 68 patients as group II (>8.7). In patients with high TyG index, left atrial volume index (LAVi) (p < .001) LV mass index (LVMI) (p = .016), E/e' ratio (p < .001) increased, and e' velocity (p < .001) and E/A ratio (p = .028) decreased. There was a statistically significant correlation between TyG index and these parameters (all p > .05). Stepwise multiple regression analysis demonstrated that the relationship of TyG index with LV diastolic function and structure was independent of potential confounders (all p < .001).
Conclusion: This study suggest that a high TyG index is related to LV diastolic functional impairment and structure abnormality in newly diagnosed hypertensive patients in the absence of diabetes or CVD.
简介:左室舒张功能障碍和结构异常是高血压(HTN)常见的心脏改变，除高血压(BP)外，还有其他因素可能在这些改变中起作用。本研究的目的是揭示甘油三酯葡萄糖(TyG)指数，胰岛素抵抗(IR)的新参数，与高血压患者左室舒张功能和结构的关系。材料和方法:本研究共纳入119例新诊断、未治疗、无糖尿病和/或心血管并发症的高血压患者。IR用ln[空腹TG (mg/dL) ×空腹血糖(mg/dL)/2]计算的TyG指数估算。行二维及多普勒超声心动图检查，评估左室舒张功能及结构。结果:根据TyG指数中位数，51例患者被分为I组(8.7)。TyG指数高的患者左房容积指数(LAVi) (p p = 0.016)、E/ E′比值(p p p = 0.028)降低。TyG指数与这些参数的相关性均有统计学意义(p > 0.05)。逐步多元回归分析显示，TyG指数与左室舒张功能和结构的关系独立于潜在的混杂因素(均p)。结论:本研究提示，在没有糖尿病或CVD的新诊断高血压患者中，TyG指数高与左室舒张功能损害和结构异常有关。
期刊介绍：
Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions.
One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field.
The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.
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