Literature review of the mechanisms of acute kidney injury secondary to acute liver injury.

Esther Platt, Enriko Klootwijk, Alan Salama, Brian Davidson, Francis Robertson
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引用次数: 3

Abstract

People exposed to liver ischaemia reperfusion (IR) injury often develop acute kidney injury and the combination is associated with significant morbidity and mortality. Molecular mediators released by the liver in response to IR injury are the likely cause of acute kidney injury (AKI) in this setting, but the mediators have not yet been identified. Identifying the mechanism of injury will allow the identification of therapeutic targets which may modulate both liver IR injury and AKI following liver IR injury.

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急性肾损伤继发于急性肝损伤机制的文献综述。
暴露于肝缺血再灌注(IR)损伤的人经常发生急性肾损伤,其合并与显著的发病率和死亡率相关。在这种情况下,肝脏响应IR损伤释放的分子介质可能是急性肾损伤(AKI)的原因,但这些介质尚未被确定。确定损伤机制将有助于确定可能调节肝IR损伤和肝IR损伤后AKI的治疗靶点。
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