Bioelectrical Impedance Vector Pattern and Biomarkers of Physical Functioning of Prostate Cancer Survivors in Rehabilitation.

IF 2.3 Q1 REHABILITATION Rehabilitation Process and Outcome Pub Date : 2021-12-16 eCollection Date: 2021-01-01 DOI:10.1177/11795727211064156
Alexander Stäuber, Marc Heydenreich, Peter R Wright, Steffen Großmann, Niklas Grusdat, Dirk-Henrik Zermann, Henry Schulz
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引用次数: 1

Abstract

Background: Knowledge of clinically established factors of physical function such as body composition, bioelectrical phase angle (PhA) and handgrip strength (HGS) with mortality predictive and health-related relevance is limited in prostate cancer survivors (PCS). Therefore, the aim of this study was to characterise and compare body composition data of PCS with extensive reference data as well as to analyse PhA and HGS and the prevalence of critical prognostic values at an early stage of cancer survivorship.

Methods: One hundred and forty-eight PCS were examined at the start (T1) and end (T2) of a 3-week hospitalised urooncological rehabilitation, which began median 28 days after acute cancer therapy. Examinations included a bioimpedance analysis and HGS test. Comparison of body composition between PCS and reference data was performed using bioimpedance vector analysis (BIVA).

Results: BIVA of the whole PCS group showed abnormal physiology with a cachectic state and a state of overhydration/oedema, without significant changes between T1 and T2. The age- and BMI-stratified subgroup analysis showed that PCS aged 60 years and older had this abnormal pattern compared to the reference population. HGS (T1: 38.7 ± 8.9 vs T2: 40.8 ± 9.4, kg), but not PhA (T1/T2: 5.2 ± 0.7, °), changed significantly between T1 and T2. Values below a critical threshold reflecting a potentially higher risk of mortality and impaired function were found for PhA in 20% (T1) and 22% (T2) of PCS and in 41% (T1) and 29% (T2) for HGS.

Conclusions: BIVA pattern and the prevalence of critically low HGS and PhA values illustrate the necessity for intensive continuation of rehabilitation and survivorship care especially in these 'at risk' cases. The routine assessment of body composition, PhA and HGS offer the opportunity to conduct a risk stratification for PCS and could help personalising and optimising treatment in rehabilitation and ongoing survivorship care.

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前列腺癌康复患者生理功能的生物电阻抗矢量模式和生物标志物。
背景:前列腺癌幸存者(PCS)对临床确定的身体功能因素,如身体成分、生物电相角(PhA)和握力(HGS)与死亡率预测和健康相关的知识有限。因此,本研究的目的是将PCS的身体成分数据与广泛的参考数据进行表征和比较,并分析PhA和HGS以及早期癌症生存期关键预后价值的流行情况。方法:148例PCS在急性肿瘤治疗后中位28天开始的为期3周的泌尿肿瘤住院康复治疗的开始(T1)和结束(T2)进行检查。检查包括生物阻抗分析和HGS测试。采用生物阻抗矢量分析(BIVA)将PCS与参考数据进行体成分比较。结果:整个PCS组BIVA均出现生理异常,表现为病毒质状态和过水合/水肿状态,T1与T2间无明显变化。年龄和bmi分层亚组分析显示,与参考人群相比,60岁及以上的PCS具有这种异常模式。HGS (T1: 38.7±8.9 vs T2: 40.8±9.4,kg), PhA (T1/T2: 5.2±0.7,°)在T1和T2之间变化不显著。20% (T1)和22% (T2)的PCS患者和41% (T1)和29% (T2)的HGS患者的PhA低于反映潜在更高死亡和功能受损风险的临界阈值。结论:BIVA模式和严重低HGS和PhA值的流行说明了加强康复和生存护理的必要性,特别是在这些“高危”病例中。对身体成分、PhA和HGS的常规评估提供了对PCS进行风险分层的机会,可以帮助个性化和优化康复治疗和持续的生存护理。
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