Correlation of Preoperative Serum and Intraoperative Peritoneal Lavage Fluid Ca-125 Levels with Postoperative Tumor Histology in Patients with Endometrial Cancer: A Prospective-Controlled Study.

IF 2.1 4区 医学 Q2 SURGERY Journal of Investigative Surgery Pub Date : 2022-06-01 Epub Date: 2022-01-06 DOI:10.1080/08941939.2021.2024307
Suleyman Gunhan Doluoglu, Mehmet Karaca, Onur Erol
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Abstract

Background: The role of Ca-125 in endometrial cancer is not fully known. Some authors have reported high Ca-125 levels in patients with recurrent or advanced endometrial cancer, whereas others have stated that Ca-125 levels and the advance of the disease were not correlated in endometrial cancer. This makes it inevitable for clinicians to search for different measurement methods or interpretation of the present tumor markers. The aim of this study was to evaluate the relationship between Ca-125 values of the serum and abdominal lavage fluid and postoperative histopathological parameters in patients with endometrial carcinoma.

Methods: The study included patients who were diagnosed with endometrial cancer in the Gynecology Clinic and were planned to undergo surgery. The correlations of clinicopathological parameters with preoperative values of Ca-125 measured from serum and abdominal lavage fluid were investigated. The Spearman correlation test was applied in the analysis of correlations of serum and abdominal lavage fluid Ca-125 values with postoperative tumor characteristics.

Results: The serum Ca-125 values were determined to be positively correlated with surgical stage, tumor diameter, and lymph node involvement (p = 0.03; p = 0.04; and p = 0.01, respectively). No correlation was determined between tumor grade and serum Ca-125 level. The level of Ca-125 in the abdominal lavage fluid was observed to be correlated with surgical stage and tumor grade, but not with tumor diameter or lymph node involvement (p = 0.01, p = 0.04, respectively).

Conclusions: The value of Ca-125 in the abdominal lavage fluid has a positive correlation with the surgical stage and tumor grade in patients with endometrial carcinoma.

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子宫内膜癌患者术前血清和术中腹腔灌洗液Ca-125水平与术后肿瘤组织学的相关性:一项前瞻性对照研究
背景:Ca-125在子宫内膜癌中的作用尚不完全清楚。一些作者报道了复发或晚期子宫内膜癌患者的高Ca-125水平,而另一些作者则指出,Ca-125水平与子宫内膜癌的进展无关。这使得临床医生不可避免地要寻找不同的测量方法或对现有肿瘤标志物的解释。本研究的目的是评估子宫内膜癌患者血清和腹腔灌洗液Ca-125值与术后组织病理学参数的关系。方法:研究对象为在妇科门诊确诊为子宫内膜癌并计划行手术治疗的患者。探讨临床病理参数与术前血清及腹腔灌洗液钙-125测定值的相关性。应用Spearman相关检验分析血清和腹腔灌洗液Ca-125值与术后肿瘤特征的相关性。结果:血清Ca-125值与手术分期、肿瘤直径、淋巴结累及程度呈正相关(p = 0.03;p = 0.04;p = 0.01)。肿瘤分级与血清Ca-125水平无相关性。腹腔灌洗液Ca-125水平与手术分期和肿瘤分级相关,但与肿瘤直径和淋巴结累及无关(p = 0.01, p = 0.04)。结论:子宫内膜癌患者腹腔灌洗液Ca-125值与手术分期及肿瘤分级呈正相关。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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