Iron Deficiency in Heart Failure: Characteristics and Treatment.

IF 1.1 Q4 GERIATRICS & GERONTOLOGY Current Geriatrics Reports Pub Date : 2021-01-01 Epub Date: 2021-11-25 DOI:10.1007/s13670-021-00370-w
Ryan C Martin, Dusty Lisi
{"title":"Iron Deficiency in Heart Failure: Characteristics and Treatment.","authors":"Ryan C Martin,&nbsp;Dusty Lisi","doi":"10.1007/s13670-021-00370-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of the review: </strong>Iron deficiency in heart failure has been associated with impaired functional capacity and quality of life. The purpose of this paper is to review mechanisms of iron homeostasis and current clinical data exploring mechanisms of iron repletion in heart failure.</p><p><strong>Recent finding: </strong>Multiple international societies now advise iron repletion for symptomatic heart failure patients with iron deficiency. Due to the chronic inflammation in heart failure, iron deficiency in heart failure is classically defined as ferritin < 100 µg/L or ferritin 100-300 µg/L and transferrin saturation < 20%. Multiple randomized clinical trials have demonstrated benefit from intravenous iron repletion, though studies have predominantly focused on functional capacity and quality of life. A recent study, AFFIRM-AHF, supports the treatment of iron deficiency identified during acute heart failure admissions, noting a reduction in future heart failure hospitalizations. Studies examining iron repletion in patients with heart failure with preserved ejection fraction are currently in process.</p><p><strong>Summary: </strong>Iron homeostasis is maintained predominantly through the regulation of iron absorption, keeping iron levels tightly controlled in the normal state regardless of iron intake. In chronic heart failure however, iron homeostasis becomes dysregulated with resulting iron deficiency in many patients, with and without associated anemia. Iron is a critical element not only for erythropoiesis and oxygen carrying, but also for energy production at the level of the mitochondria and in other cell processes. We thus propose a standardized approach be utilized to screen and treat heart failure patients with iron deficiency.</p>","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613520/pdf/","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Geriatrics Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13670-021-00370-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/11/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 4

Abstract

Purpose of the review: Iron deficiency in heart failure has been associated with impaired functional capacity and quality of life. The purpose of this paper is to review mechanisms of iron homeostasis and current clinical data exploring mechanisms of iron repletion in heart failure.

Recent finding: Multiple international societies now advise iron repletion for symptomatic heart failure patients with iron deficiency. Due to the chronic inflammation in heart failure, iron deficiency in heart failure is classically defined as ferritin < 100 µg/L or ferritin 100-300 µg/L and transferrin saturation < 20%. Multiple randomized clinical trials have demonstrated benefit from intravenous iron repletion, though studies have predominantly focused on functional capacity and quality of life. A recent study, AFFIRM-AHF, supports the treatment of iron deficiency identified during acute heart failure admissions, noting a reduction in future heart failure hospitalizations. Studies examining iron repletion in patients with heart failure with preserved ejection fraction are currently in process.

Summary: Iron homeostasis is maintained predominantly through the regulation of iron absorption, keeping iron levels tightly controlled in the normal state regardless of iron intake. In chronic heart failure however, iron homeostasis becomes dysregulated with resulting iron deficiency in many patients, with and without associated anemia. Iron is a critical element not only for erythropoiesis and oxygen carrying, but also for energy production at the level of the mitochondria and in other cell processes. We thus propose a standardized approach be utilized to screen and treat heart failure patients with iron deficiency.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
心力衰竭缺铁:特点和治疗。
综述目的:心力衰竭患者缺铁与功能能力和生活质量受损有关。本文的目的是回顾铁质稳态的机制和目前的临床资料探讨铁质补充在心力衰竭中的机制。最近的发现:多个国际协会现在建议对缺铁的症状性心力衰竭患者补充铁。由于心力衰竭的慢性炎症,心力衰竭的缺铁被经典地定义为铁蛋白。摘要:铁的体内平衡主要是通过调节铁的吸收来维持的,无论铁的摄入量如何,铁的水平都被严格控制在正常状态。然而,在慢性心力衰竭中,许多患者伴或不伴贫血,铁体内平衡失调,导致缺铁。铁不仅是红细胞生成和运氧的关键元素,而且在线粒体水平和其他细胞过程中也是能量产生的关键元素。因此,我们提出了一种标准化的方法来筛选和治疗缺铁性心力衰竭患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Current Geriatrics Reports
Current Geriatrics Reports Medicine-Geriatrics and Gerontology
CiteScore
2.20
自引率
0.00%
发文量
4
期刊介绍: This journal aims to offer in-depth review articles on the most recent innovative publications in geriatrics and gerontology. By providing clear, insightful contributions by international experts, the journal intends to serve clinicians and researchers involved in the diagnosis, management, treatment, prevention, and study of patients affected by age-related conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as the age-related change in cognitive function, the influence of genetics on neurodegenerative disorders, and traumatic brain injury and dementia. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board of more than 20 members reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.
期刊最新文献
Considerations for Left Atrial Appendage Closure in Older Adults Health Behavior Change to Mitigate Dementia Risk: An Updated Review Geriatric Facial Dermatosis Title: Pruritus in the Elderly: Differential Diagnosis and Management Non-Melanoma Skin Cancer Treatment Updates in the Elderly
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1