Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2022-01-01 Epub Date: 2021-10-05 DOI:10.1002/wsbm.1538
Chao-Yue Cui, Qiwei Chen, Qian He, Chong Chen, Rong-Min Zhang, Youjun Feng, Jian Sun
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引用次数: 5

Abstract

Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance. This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology.

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替加环素耐药性的可转移性:扩展Tet(X)家族的表征。
四环素及其衍生物替加环素是治疗革兰氏阴性细菌感染的临床选择。破坏四环素类抗生素的移动Tet(X)酶的出现对抗菌治疗和食品/环境安全提出了重大挑战。在这里,我们介绍了越来越多的Tet(X)变体的最新情况。介绍了Tet(X)酶的结构和作用,并讨论了其进化起源。此外,还给出了潜在的Tet(X)抑制剂。这项小型综述可能有助于更好地了解Tet(X)介导的替加环素耐药性。本文分类为:传染病>遗传学/基因组学/表观遗传学>环境因素传染病>分子与细胞生理学。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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