Fabrication, Characterization and Toxicity Evaluation of Chemically Cross linked Polymeric Network for Sustained Delivery of Metoprolol Tartrate.

IF 1.8 4区化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2021-12-09 eCollection Date: 2021-01-01 DOI:10.1080/15685551.2021.2003995

Sumaira, Ume Ruqia Tulain, Alia Erum, Muhammad Ajaz Hussain, Sidra, Nadia Shamshad Malik, Ayesha Rashid, Rizwana Kausar, Nitasha Gohar, Nariman Shahid, Mahwish Siddiqui

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Abstract

Natural mucilages are auspicious biodegradable polymeric materials. The aim of the present research work was to elucidate the characteristics of quince mucilage-based polymeric network for sustained delivery of metprolol tartrate and its toxicity evaluation. Mucilage was extracted by hot water extraction, and characterization of quince mucilage was accomplished by using Fourier transform infrared (FTIR) spectroscopy. Different batches of quince mucilage polymeric network were prepared by free radical polymerization by utilizing varying ratios of quince mucilage, acrylamide and crosslinker. Degree of swelling depends on concentration of mucilage, monomer and also on crosslinking density of polymeric network. FTIR illustrates proficient grafting, and morphological (scanning electron microscopy) analysis signified porous design. Hence, quince mucilage-based design was encouraging for sustained delivery of metprolol tartrate and acute toxicity evaluation proved that mucilage-based network was safe for oral drug delivery system.

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用于酒石酸美托洛尔持续给药的化学交联聚合物网络的制造、表征和毒性评估

天然粘液是一种可生物降解的聚合材料。本研究工作旨在阐明基于榅桲粘液的聚合物网络在持续递送酒石酸甲泼洛尔方面的特性及其毒性评估。研究人员采用热水提取法提取了榅桲粘液，并利用傅立叶变换红外光谱（FTIR）对榅桲粘液进行了表征。利用不同比例的榅桲粘液、丙烯酰胺和交联剂，通过自由基聚合法制备了不同批次的榅桲粘液聚合网络。溶胀程度取决于粘液、单体的浓度以及聚合物网络的交联密度。傅立叶变换红外光谱（FTIR）显示了良好的接枝，形态学（扫描电子显微镜）分析表明了多孔设计。因此，基于榅桲粘液的设计在持续给药酒石酸甲泼洛尔方面是令人鼓舞的，急性毒性评估证明基于粘液的网络是安全的口服给药系统。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications