Patho-mechanisms of the origins of bronchopulmonary dysplasia.

IF 2.4 Q1 PEDIATRICS Molecular and cellular pediatrics Pub Date : 2021-12-11 DOI:10.1186/s40348-021-00129-5
Mitali Sahni, Vineet Bhandari
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引用次数: 9

Abstract

Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications of prematurity, despite significant advancement in neonatology over the last couple of decades. The new BPD is characterized histopathologically by impaired lung alveolarization and dysregulated vascularization. With the increased survival of extremely preterm infants, the risk for the development of BPD remains high, emphasizing the continued need to understand the patho-mechanisms that play a role in the development of this disease. This brief review summarizes recent advances in our understanding of the maldevelopment of the premature lung, highlighting recent research in pathways of oxidative stress-related lung injury, the role of placental insufficiency, growth factor signaling, the extracellular matrix, and microRNAs.

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支气管肺发育不良起源的病理机制。
支气管肺发育不良(BPD)仍然是早产最常见的并发症之一,尽管在过去的几十年里,新生儿学取得了重大进展。新的BPD在组织病理学上以肺泡化受损和血管化失调为特征。随着极早产儿存活率的增加,BPD发展的风险仍然很高,强调继续需要了解在该疾病发展中起作用的病理机制。本文简要综述了我们对早产儿肺发育不良的最新研究进展,重点介绍了氧化应激相关肺损伤途径、胎盘功能不全、生长因子信号传导、细胞外基质和microrna的作用。
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