Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.

IF 0.9 4区 医学 Q4 PSYCHIATRY Turk Psikiyatri Dergisi Pub Date : 2021-01-01 DOI:10.5080/u25686
Gülcan Güleç, Didem Turgut Coşan, Fezan Mutlu Şahin, İbrahim Uğur Çaliş, Melis Danişman Sonkurt, Ferdi Köşger, Altan Eşsizoğlu
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引用次数: 1

Abstract

Objective: In this study, we aimed to investigate the Neurexin 3 gene (NRXN3) polymorphisms in the rs 221473, rs 221497, rs1004212 and rs11624704 regions in relation to nicotine use disorder (NUD) in the Turkish population.

Method: Power analysis indicated that the NUD group and the control group of this study should each comprise 200 participants in the 18-65 year age range. The NUD group consisted of individuals without a psychiatric first axis disorder except for NUD, mental retardation, past head trauma or a neurological disorder, who had smoked minimally10 cigarettes per day for at least 1 year. The control group included individuals without a serious chronic physical illness, a previous psychiatric disorder or mental retardation and who responded "no" to the question "have you ever smoked?" A sociodemographic questionnaire and the Fageström nicotine dependence scale (FNDS) for the NUD group were utilized. Venous blood samples of all participants were taken into tubes containing EDTA (ethylene daimine tetra acetic acid) for DNA extraction. Duplex fluorescence melting curve analysis was used for genotype detection and differentiation.

Results: The individuals carrying the AC allele and the AG allele at the rs11624704 and the rs1004212 regions respectively had a high risk of being addicted to cigarettes.

Conclusion: This is first study investigating the relationship of the NRXN3 gene and nicotine addiction in the Turkish population. It was observed that the risk of NUD in the Turkish population may be related to the Neurexin gene.

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尼古丁使用障碍与Neurexin 3基因多态性的关系
目的:在本研究中,我们旨在研究土耳其人群中rs221473、rs221497、rs1004212和rs11624704区域Neurexin 3基因(NRXN3)多态性与尼古丁使用障碍(NUD)的关系。方法:功率分析表明,本研究NUD组和对照组各有200名参与者,年龄在18-65岁之间。NUD组由没有精神第一轴障碍的个体组成,除了NUD,智力迟钝,过去的头部创伤或神经障碍,每天至少抽10支烟至少1年。对照组包括没有严重慢性身体疾病、以前没有精神障碍或智力迟钝的人,他们对“你曾经吸烟吗?”这个问题回答“没有”。NUD组采用社会人口调查问卷和Fageström尼古丁依赖量表(FNDS)。将所有受试者的静脉血样本放入含有EDTA(乙二胺四乙酸)的试管中进行DNA提取。双荧光熔融曲线分析用于基因型检测和分化。结果:分别在rs11624704和rs1004212位点携带AC等位基因和AG等位基因的个体具有较高的吸烟成瘾风险。结论:这是首次在土耳其人群中调查NRXN3基因与尼古丁成瘾关系的研究。据观察,土耳其人群NUD的风险可能与Neurexin基因有关。
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来源期刊
CiteScore
1.30
自引率
11.10%
发文量
15
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