{"title":"Beyond Amelogenesis Imperfecta Mutations: Hypomorphic Forms.","authors":"Alexandre Rezende Vieira","doi":"10.1159/000520764","DOIUrl":null,"url":null,"abstract":"<p><p>Mutations in several genes can lead to amelogenesis imperfecta. These same genes and other members of their pathways quite possibly may also contribute to individual susceptibility to dental caries and/or erosive tooth wear. This chapter provides an analysis of the function of the genes which, when mutated, cause amelogenesis imperfecta and discusses how mechanisms involving hypomorphic alleles in one or more genes, methylation changes, and imprinting disorders could be underlying individual susceptibility to dental caries and/or erosive tooth wear.</p>","PeriodicalId":35771,"journal":{"name":"Monographs in Oral Science","volume":"30 ","pages":"20-35"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Monographs in Oral Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000520764","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 0
Abstract
Mutations in several genes can lead to amelogenesis imperfecta. These same genes and other members of their pathways quite possibly may also contribute to individual susceptibility to dental caries and/or erosive tooth wear. This chapter provides an analysis of the function of the genes which, when mutated, cause amelogenesis imperfecta and discusses how mechanisms involving hypomorphic alleles in one or more genes, methylation changes, and imprinting disorders could be underlying individual susceptibility to dental caries and/or erosive tooth wear.
期刊介绍：
For two decades, ‘Monographs in Oral Science’ has provided a source of in-depth discussion of selected topics in the sciences related to stomatology. Senior investigators are invited to present expanded contributions in their fields of special expertise. The topics chosen are those which have generated a long-standing interest, and on which new conceptual insights or innovative biotechnology are making considerable impact. Authors are selected on the basis of having made lasting contributions to their chosen field and their willingness to share their findings with others.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
