Cardiac Involvement by Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma: An Unusual Presentation in a Patient with Human Immunodeficiency Virus.

IF 0.7 Q4 PATHOLOGY Case Reports in Pathology Pub Date : 2022-01-17 eCollection Date: 2022-01-01 DOI:10.1155/2022/1298121
Elena M Fenu, Michael W Beaty, Tiffany E O'Neill, Stacey S O'Neill
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引用次数: 2

Abstract

Human immunodeficiency virus (HIV) infection predisposes patients to the development of lymphomas, both due to immune suppression and coinfection with viruses with oncogenic potential. Coinfection with human herpesvirus 8 (HHV8) in particular has been associated with the development of aggressive lymphomas, including primary effusion lymphoma and diffuse large B-cell lymphoma (DLBCL). Herein, we report an unusual case of HHV8-positive DLBCL with extensive cardiac involvement which was diagnosed at autopsy in a patient with long-standing untreated HIV infection.

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人类疱疹病毒8阳性弥漫性大b细胞淋巴瘤累及心脏:人类免疫缺陷病毒患者的不寻常表现
人类免疫缺陷病毒(HIV)感染使患者易患淋巴瘤,这既是由于免疫抑制,也是由于与具有致癌潜力的病毒共同感染。人类疱疹病毒8型(HHV8)的共同感染尤其与侵袭性淋巴瘤的发展有关,包括原发性渗出性淋巴瘤和弥漫性大B细胞淋巴瘤(DLBCL)。在此,我们报告了一例不寻常的HHV8阳性DLBCL病例,该病例在尸检中被诊断为长期未经治疗的HIV感染患者,并伴有广泛的心脏受累。
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审稿时长
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