Prognostic value of the maximum standardized uptake value for the locoregional control in early glottic cancer.

IF 1.8 Q3 ONCOLOGY Radiation Oncology Journal Pub Date : 2021-12-01 Epub Date: 2021-12-14 DOI:10.3857/roj.2021.00507
Donghyun Kim, Yongkan Ki, Jihyeon Joo, Hosang Jeon, Dahl Park, Jiho Nam, Wontaek Kim
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Abstract

Purpose: To evaluate the prognostic value of the pretreatment maximum standardized uptake value (SUVmax) for locoregional control (LRC) of early glottic cancer treated with primary radiotherapy.

Materials and methods: We retrospectively reviewed the medical records of 101 patients with T1-T2N0 glottic cancer treated with helical tomotherapy between 2013 and 2016. The clinical T-stages were T1 in 87 (86.1%) and T2 in 14 (13.9%) patients. The median total dose was 63 Gy (63-67.5 Gy) in 2.25 Gy per fraction. The survival outcomes were plotted using Kaplan-Meier curves. Receiver operating characteristic curves were used to assess the optimal SUVmax cut-off value for predicting locoregional recurrence.

Results: The median follow-up period was 58 months (range, 11 to 90 months). The 5-year overall survival (OS) and locoregional recurrence-free survival rates were 96.8% and 85.4%, respectively. The median pretreatment SUVmax of the primary tumor for all 101 patients was 2.3 (range, 1.1 to 9.1). The best cut-off value for SUVmax for predicting LRC was 3.3, with a sensitivity of 78.6% and specificity of 73.6%. Univariate analysis showed that T-stage, overall treatment time (≥43 days), and high SUVmax (≥3.3) were significant predictors of LRC. Multivariate analysis showed that LRC was independently affected by a high SUVmax (≥3.3) (hazard ratio = 5.505, p = 0.020).

Conclusion: High pretreatment SUVmax (≥3.3) is a negative prognostic factor for LRC in early glottic cancer patients treated with primary radiotherapy.

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最大标准化摄取值对早期声门癌局部控制的预后价值。
目的:评价早期声门癌初治放疗前最大标准化摄取值(SUVmax)对局部控制(LRC)的预后价值。材料与方法:回顾性分析2013 - 2016年101例接受螺旋断层治疗的T1-T2N0型声门癌患者的病历。临床t分期为T1期87例(86.1%),T2期14例(13.9%)。中位总剂量为63 Gy (63-67.5 Gy),每个分数为2.25 Gy。生存结果用Kaplan-Meier曲线绘制。使用受试者工作特征曲线评估预测局部复发的最佳SUVmax截止值。结果:中位随访时间为58个月(11 ~ 90个月)。5年总生存率(OS)为96.8%,局部无复发生存率为85.4%。101例患者原发肿瘤的中位预处理SUVmax为2.3(范围1.1 - 9.1)。SUVmax预测LRC的最佳临界值为3.3,敏感性为78.6%,特异性为73.6%。单因素分析显示,t分期、总治疗时间(≥43天)和高SUVmax(≥3.3)是LRC的显著预测因子。多因素分析显示,高SUVmax(≥3.3)是LRC的独立影响因素(风险比= 5.505,p = 0.020)。结论:高预处理SUVmax(≥3.3)是早期声门癌初次放疗患者LRC的不良预后因素。
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来源期刊
CiteScore
3.50
自引率
4.30%
发文量
24
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