The Effect of Vitamin D Deficiency in Chronic Obstructive Pulmonary Disease.

IF 0.8 Q4 RESPIRATORY SYSTEM Turkish Thoracic Journal Pub Date : 2021-05-01 DOI:10.5152/TurkThoracJ.2021.19108

Hatice Uluçoban, Hülya Dirol, Tülay Özdemir

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引用次数: 2

Abstract

Objective: It has been suggested that Vitamin D Deficiency (VDD) worsens lung functions and COPD lowers vitamin D levels, but this has not been proven yet.

Material and methods: The study was carried out between January 2014 and September 2015. All the COPD patients with 25 (OH) D3 measurements were included in this study. The patients < 40-year-old, or with a smoking history of less than 10 package-year, or with asthma, bronchiectasis, pneumonia, tuberculosis, cancer, were excluded from the study. Medical records about age, gender, pulmonary function test, body mass index (BMI), annual exacerbations/hospitalizations, modified British Medical Research Council (mMRC) level and serum 25 (OH) D3 were obtained.

Results: The data of 216 (83.8% male) patients were examined in the study. The mean age was 66.88 ± 10.3 years. The mean vitamin D level was 21.1 ± 13.73 ng/mL. Of the patients, 57.9% had VDD, and even 19.9% were in severe VDD. Only 26.4% had adequate vitamin D level. There was a significant in BMI, FEV1, FVC, annual exacerbation and hospitalisations between the patients with vitamin D levels > 20 ng / mL and ≤ 20 ng / mL. Vitamin D level of patients with mMRC level 1 was significantly higher than those with mMRC 2, 3, 4 (respectively P = .03; P = .026; P = .014).

Conclusion: In this study, we found that lung function was worse in COPD patients with VDD and VDD increased with increasing severity of COPD.

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维生素D缺乏对慢性阻塞性肺疾病的影响。

目的:已有研究表明，维生素D缺乏(VDD)会使肺功能恶化，而慢性阻塞性肺病(COPD)会降低维生素D水平，但这一点尚未得到证实。材料与方法:研究时间为2014年1月至2015年9月。所有25 (OH) D3检测的COPD患者均纳入本研究。年龄< 40岁，或吸烟史小于10包年，或患有哮喘、支气管扩张、肺炎、肺结核、癌症的患者被排除在研究之外。获得患者的年龄、性别、肺功能检查、体重指数(BMI)、年加重/住院次数、修改后的英国医学研究理事会(mMRC)水平和血清25 (OH) D3等医疗记录。结果:共纳入216例患者，其中男性83.8%。平均年龄66.88±10.3岁。平均维生素D水平为21.1±13.73 ng/mL。57.9%的患者有VDD，其中19.9%为重度VDD。只有26.4%的人有足够的维生素D水平。维生素D水平> 20 ng / mL与≤20 ng / mL患者的BMI、FEV1、FVC、年加重率、住院率差异均有统计学意义，其中维生素D水平为1的患者的维生素D水平显著高于2、3、4的患者(P = .03;P = 0.026;P = .014)。结论:本研究中，我们发现COPD合并VDD患者肺功能较差，且VDD随COPD严重程度的增加而增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Thoracic Journal Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

11.10%

发文量

期刊介绍： Turkish Thoracic Journal (Turk Thorac J) is the double-blind, peer-reviewed, open access, international publication organ of Turkish Thoracic Society. The journal is a quarterly publication, published on January, April, July, and October and its publication language is English. Turkish Thoracic Journal started its publication life following the merger of two journals which were published under the titles “Turkish Respiratory Journal” and “Toraks Journal” until 2007. Archives of both journals were passed on to the Turkish Thoracic Journal. The aim of the journal is to convey scientific developments and to create a dynamic discussion platform about pulmonary diseases. With this intent, the journal accepts articles from all related scientific areas that address adult and pediatric pulmonary diseases, as well as thoracic imaging, environmental and occupational disorders, intensive care, sleep disorders and thoracic surgery. Clinical and research articles, reviews, statements of agreement or disagreement on controversial issues, national and international consensus reports, abstracts and comments of important international articles, interesting case reports, writings related to clinical and practical applications, letters to the editor, and editorials are accepted.