Beneficial Effect of Saharan Propolis on Glucose Metabolism in Streptozotocin- induced Diabetic Rats.

Q2 Medicine Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2021-01-01 DOI:10.2174/1871529X21666211118141935

Mourad Akdad, Bouchra Azzaoui, Mohamed Eddouks

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Abstract

Aims: The aim of the study was to evaluate the antihyperglycemic activity of propolis from Saharan region of Morocco.

Background: Propolis is known from ancient times for its beneficial action on health.

Objective: The study aimed to evaluate the effect of Moroccan propolis aqueous extract from the desert region on glycemia and lipid metabolism.

Methods: The antihyperglycemic and antidyslipidemic activities of Moroccan propolis aqueous extract were evaluated in streptozotocin-induced diabetic rats. Glycemia was monitored during acute (6h) and subchronic treatments. Histopathological analysis of the liver and the serum lipid profile was also evaluated in addition to the glucose tolerance.

Results: This work demonstrated that the aqueous extract of Moroccan propolis exhibited a significant antihyperglycemic effect in diabetic rats. Histopathological data demonstrated that propolis acts positively on the liver of diabetic rats. In addition, the preliminary phytochemical screening revealed that Moroccan propolis contains several phytochemicals. Finally, Moroccan propolis had a potent antioxidant activity which may be due to the richness in polyphenols content (90.91 mg EAG/1 g of extract).

Conclusion: The present study shows that Moroccan propolis from the hot desert region possesses a potent antihyperglycemic effect.

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撒哈拉蜂胶对链脲佐菌素诱导的糖尿病大鼠葡萄糖代谢的有益影响。

目的:研究摩洛哥撒哈拉地区蜂胶的降血糖活性。背景:蜂胶自古以来就以其有益健康的作用而闻名。目的:研究沙漠地区摩洛哥蜂胶水提物对血糖和脂质代谢的影响。方法:观察摩洛哥蜂胶水提物对链脲佐菌素诱导的糖尿病大鼠的降糖、降脂作用。在急性(6小时)和亚慢性治疗期间监测血糖。除了葡萄糖耐量外，还对肝脏和血脂进行了组织病理学分析。结果:摩洛哥蜂胶水提物对糖尿病大鼠具有明显的降血糖作用。组织病理学结果表明蜂胶对糖尿病大鼠肝脏有积极作用。此外，初步的植物化学筛选显示摩洛哥蜂胶含有几种植物化学物质。最后，摩洛哥蜂胶具有强大的抗氧化活性，这可能是由于其丰富的多酚含量(90.91 mg EAG/1 g提取物)。结论:本研究表明来自炎热沙漠地区的摩洛哥蜂胶具有有效的降糖作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.