Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies among HIV Infected Individuals Attending ART Centre at Pune: A Cross-Sectional Study.

IF 2.2 Q3 INFECTIOUS DISEASES Journal of the International Association of Providers of AIDS Care Pub Date : 2022-01-01 DOI:10.1177/23259582221077943

Manisha Ghate, Pallavi Shidhaye, Shraddha Gurav, Keshav Gadhe, Varsha Kale, Preeti Jain, Madhuri Thakar

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引用次数: 4

Abstract

Background: We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. Methods: This cross-sectional study was conducted between March 2021 and June 2021. Demographic and clinical information related to coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples were collected and tested for anti-SARS-CoV-2 IgG antibodies using commercial ELISA. Results: Of the 405 HIV infected individuals enrolled in the study, 223(55.1%) were females. Mean age and CD4 count of participants were 42 years (SD: 10) and 626 cells/mm³ (SD: 284) respectively. A total of 382 (95%) PLHIV were virologically suppressed. The seropositivity against SARS-CoV-2 was found in 221 PLHIV (54.6%, 95% CI: 49.7-59.4). No significant association was found between demographic or clinical factors and seropositivity. Conclusion: A high prevalence of anti-SARS-CoV-2 IgG antibodies was found among PLHIV attending ART centre indicating an exposure to the virus among them.

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在浦那抗逆转录病毒治疗中心接受治疗的HIV感染者中抗sars - cov -2 IgG抗体的血清阳性率:一项横断面研究

背景:本研究旨在测定印度浦那地区HIV感染者(PLHIV)的抗sars - cov -2 IgG抗体水平。方法:该横断面研究于2021年3月至2021年6月进行。以结构化问卷形式记录2019冠状病毒病(COVID-19)的人口学和临床相关信息。采集血样，使用商用ELISA检测抗sars - cov -2 IgG抗体。结果:在纳入研究的405名HIV感染者中，223名(55.1%)为女性。参与者的平均年龄和CD4计数分别为42岁(SD: 10)和626个细胞/mm3 (SD: 284)。共有382例(95%)PLHIV病毒被病毒学抑制。221例PLHIV血清SARS-CoV-2阳性(54.6%，95% CI: 49.7 ~ 59.4)。未发现人口统计学或临床因素与血清阳性之间有显著关联。结论:在抗逆转录病毒治疗中心就诊的PLHIV患者中发现了高流行率的抗sars - cov -2 IgG抗体，表明其中存在病毒暴露。

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