Interleukin-4 can play a role in allergic rhinitis patient during treatment with Zataria multiflora.

Q2 Medicine Clinical and Molecular Allergy Pub Date : 2022-02-10 DOI:10.1186/s12948-022-00169-w

Nazila Ariaee, Yaser Yadegari, Mohamad Shabestari, Javad Asili, Maryam Panahi, Jalal Ghorbani, Farahzad Jabbari

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引用次数: 1

Abstract

Background: Allergic rhinitis is a widespread disorder across the globe. The Shirazi thyme (Zataria multiflora) has been shown to have considerable antioxidant and anti-inflammatory properties. This study assessed the effect of this herbal product on alterations in inflammatory/anti-inflammatory cytokines.

Method: This study was conducted on the bank sample before and after the intervention to measure interleukin-4, interleukin-5, and interferon -γ levels with the ELISA test method in a supernatant taken from the PBMC cell culture from 30 allergic rhinitis patients.

Results: The IL-4 level had no significant difference between the two groups before the treatment. However, it had a significant increase in the case group after the treatment. The IL-5 level was significantly higher in the case group before the treatment. Nevertheless, there were no significant differences between the case and control groups after the treatment. Similarly, no significant differences were observed between the two groups considering IFN-γ before and after the treatment.

Conclusion: Consuming thyme with an increase in anti-inflammatory cytokine IL-4 and a decrease in IL-5 cytokine control inflammation and improvement in allergic rhinitis symptoms. Clinical trial details This clinical trial study was recorded at 22.5.2014 in the Iran Registry of Clinical Trials code: (IRCT2016121823235N6) https://www.irct.ir/trial/19852.

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白介素-4在扎乌连治疗变应性鼻炎患者中的作用。

背景:变应性鼻炎是一种全球范围内普遍存在的疾病。Shirazi百里香(Zataria multiflora)已被证明具有相当的抗氧化和抗炎特性。本研究评估了这种草药产品对炎症/抗炎细胞因子变化的影响。方法:本研究对30例变应性鼻炎患者PBMC细胞培养上清进行干预前后的银行样本，采用ELISA法检测白细胞介素-4、白细胞介素-5、干扰素-γ水平。结果:治疗前两组患者IL-4水平差异无统计学意义。然而，在治疗后，病例组有显著增加。治疗前病例组IL-5水平明显升高。然而，治疗后，病例组与对照组之间无显著差异。同样，在治疗前后考虑IFN-γ的两组之间也没有观察到显著差异。结论:食用百里香可增加抗炎细胞因子IL-4，降低IL-5细胞因子，控制炎症，改善变应性鼻炎症状。本临床试验研究于2014年5月22日在伊朗临床试验登记处登记，编号:(IRCT2016121823235N6) https://www.irct.ir/trial/19852。

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.