Analysis of urinary VOCs using mass spectrometric methods to diagnose cancer: A review

IF 2.1 Q4 Chemistry Clinical Mass Spectrometry Pub Date : 2020-11-01 DOI:10.1016/j.clinms.2020.10.004

Bruno Ruiz Brandão da Costa , Bruno Spinosa De Martinis

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引用次数: 32

Abstract

The development of non-invasive screening techniques for early cancer detection is one of the greatest scientific challenges of the 21st century. One promising emerging method is the analysis of volatile organic compounds (VOCs). VOCs are low molecular weight substances generated as final products of cellular metabolism and emitted through a variety of biological matrices, such as breath, blood, saliva and urine. Urine stands out for its non-invasive nature, availability in large volumes, and the high concentration of VOCs in the kidneys. This review provides an overview of the available data on urinary VOCs that have been investigated in cancer-focused clinical studies using mass spectrometric (MS) techniques. A literature search was conducted in ScienceDirect, Pubmed and Web of Science, using the keywords “Urinary VOCs”, “VOCs biomarkers” and “Volatile cancer biomarkers” in combination with the term “Mass spectrometry”. Only studies in English published between January 2011 and May 2020 were selected. The three most evaluated types of cancers in the reviewed studies were lung, breast and prostate, and the most frequently identified urinary VOC biomarkers were hexanal, dimethyl disulfide and phenol; with the latter seeming to be closely related to breast cancer. Additionally, the challenges of analyzing urinary VOCs using MS-based techniques and translation to clinical utility are discussed. The outcome of this review may provide valuable information to future studies regarding cancer urinary VOCs.

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用质谱法分析尿液挥发性有机化合物诊断癌症的研究进展

发展非侵入性早期癌症检测技术是21世纪最大的科学挑战之一。一种很有前途的新兴方法是挥发性有机化合物(VOCs)的分析。挥发性有机化合物是一种低分子量物质，是细胞代谢的最终产物，通过呼吸、血液、唾液和尿液等多种生物基质释放。尿液以其非侵入性、大量可用性和肾脏中高浓度的挥发性有机化合物而突出。本文综述了在以癌症为重点的临床研究中使用质谱(MS)技术研究尿液中挥发性有机化合物的现有数据。在ScienceDirect、Pubmed和Web of Science中检索相关文献，检索关键词为“尿液VOCs”、“VOCs生物标志物”和“挥发性癌症生物标志物”，并结合“质谱”进行检索。仅选择2011年1月至2020年5月期间发表的英文研究。在回顾的研究中，评估最多的三种癌症类型是肺癌、乳腺癌和前列腺癌，最常见的尿液VOC生物标志物是己醛、二甲基二硫化物和苯酚;后者似乎与乳腺癌密切相关。此外，本文还讨论了使用基于ms的技术分析尿液挥发性有机化合物及其转化为临床应用所面临的挑战。本综述的结果可能为今后癌症尿中挥发性有机化合物的研究提供有价值的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Mass Spectrometry Chemistry-Spectroscopy

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Clinical Mass Spectrometry publishes peer-reviewed articles addressing the application of mass spectrometric technologies in Laboratory Medicine and Clinical Pathology with the focus on diagnostic applications. It is the first journal dedicated specifically to the application of mass spectrometry and related techniques in the context of diagnostic procedures in medicine. The journal has an interdisciplinary approach aiming to link clinical, biochemical and technological issues and results.