Mind Over Matter: Confronting Challenges in Post-Mortem Brain Biobanking for Glioblastoma Multiforme.

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Insights Pub Date : 2021-04-30 eCollection Date: 2021-01-01 DOI:10.1177/11772719211013359
Cassandra Griffin, Ricardo Vilain, Simon King, Sandy Nixon, Alisha Gooley, Samara Bray, James Lynam, Marjorie M Walker, Rodney J Scott, Christine Paul
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引用次数: 3

Abstract

Over the past 10 years, there has been limited progress for the treatment of brain cancer and outcomes for patients are not much improved. For brain cancer researchers, a major obstacle to biomarker driven research is limited access to brain cancer tissue for research purposes. The Mark Hughes Foundation Brain Biobank is one of the first post-mortem adult brain banks in Australia to operate with protocols specifically developed for brain cancer. Located within the Hunter New England Local Health District and operated by Hunter Cancer Biobank, the boundaries of service provided by the Brain Bank extend well into the surrounding regional and rural areas of the Local Health District and beyond. Brain cancer biobanking is challenging. There are conflicting international guidelines for best practice and unanswered questions relating to scientific, psychosocial and operational practices. To address this challenge, a best practice model was developed, informed by a consensus of existing data but with consideration of the difficulties associated with operating in regional or resource poor settings. The regional application of this model was challenged following the presentation of a donor located in a remote area, 380km away from the biobank. This required biobank staff to overcome numerous obstacles including long distance patient transport, lack of palliative care staff, death in the home and limited rural outreach services. Through the establishment of shared goals, contingency planning and the development of an informal infrastructure, the donation was facilitated within the required timeframe. This experience demonstrates the importance of collaboration and networking to overcome resource insufficiency and geographical challenges in rural cancer research programmes.

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精神高于物质:多形性胶质母细胞瘤死后脑生物银行面临的挑战。
在过去的10年里,脑癌的治疗进展有限,患者的预后也没有多大改善。对于脑癌研究人员来说,生物标志物驱动研究的一个主要障碍是为研究目的获取脑癌组织的途径有限。马克·休斯基金会脑生物银行是澳大利亚首批按照专门为脑癌制定的协议运作的成人死后脑库之一。脑库位于亨特新英格兰地方卫生区内,由亨特癌症生物银行运营,其服务范围延伸至当地卫生区的周边地区和农村地区,甚至更远。脑癌生物银行具有挑战性。关于最佳做法的国际准则相互矛盾,在科学、社会心理和业务实践方面也存在未解决的问题。为了应对这一挑战,开发了一个最佳实践模型,该模型基于对现有数据的共识,但考虑到在区域或资源贫乏环境中开展业务的困难。在距离生物库380公里远的偏远地区出现了一名捐赠者后,这一模式的区域应用受到了挑战。这就要求生物库工作人员克服许多障碍,包括远距离运送病人、缺乏姑息治疗工作人员、家中死亡和农村外联服务有限。通过确定共同目标、制定应急计划和发展非正式基础设施,在规定的时限内促进了捐赠。这一经验表明协作和建立网络对于克服农村癌症研究规划中的资源不足和地理挑战的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomarker Insights
Biomarker Insights MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.00
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
期刊最新文献
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