Therapeutic effect of two transition metal coordination polymers on ovarian cancer by regulating the expression of estrogen receptor.

IF 1.8 4区化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2022-02-09 eCollection Date: 2022-01-01 DOI:10.1080/15685551.2022.2033432

Jin Zhao, Lan Du

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Abstract

In the present study, via using a ligand featuring oxalamide groups N,N'-bis(4-phthalic acid) (H₄L), two new Cu(II) and Co(II)-containing coordination polymers with the chemical formulae of [Cu₂L(H₂O)₄]_n (1) and [Co(H₂L)(H₂O)₂]_n (2) have been successfully prepared via reaction of the corresponding metal salts with the H₄L ligand. The as-prepared two coordination polymers have been studied via the single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction and thermogravimetric analysis. Their therapeutic effect and mechanism for ovarian cancer was evaluated and explored. Firstly, the inhibitory activity of the new compounds on the proliferation of the ovarian cancer was measured with CCK-8 assay after compound treatment. Besides, the relative expression of the estrogen receptor on the ovarian cancer cells after compound treatment was also determined with real-time RT-PCR assay.

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两种过渡金属配位聚合物通过调节雌激素受体表达对卵巢癌的治疗作用。

本研究以草酰胺基团N,N′-双(4-邻苯二甲酸)(H4L)为配体，通过相应的金属盐与H4L配体反应，成功制备了化学式为[Cu2L(H2O)4] N(1)和[Co(H2L)(H2O)2] N(2)的新型含Cu(II)和Co(II)的配位聚合物。通过单晶x射线衍射、元素分析、粉末x射线衍射和热重分析对制备的两种配位聚合物进行了研究。并对其治疗卵巢癌的疗效及机制进行了评价和探讨。首先，采用CCK-8法检测新化合物对卵巢癌细胞增殖的抑制作用。此外，采用实时RT-PCR法测定复方治疗后卵巢癌细胞中雌激素受体的相对表达量。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications