Prevention of Intra-Abdominal Adhesions Using the Combination of Mediclore® and a Statin.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-01-01 Epub Date: 2021-12-03 DOI:10.1159/000519708

Jesung Park, Hyun Kang, Yoo Shin Choi, Suk-Won Suh, Soon Auck Hong, Geun Joo Choi, Woo Jung Sim

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引用次数: 3

Abstract

Purpose: This study investigated the antiadhesive effects of Mediclore®, rosuvastatin, and a combination of Mediclore and rosuvastatin in a rat adhesion model.

Methods: The adhesion models (a total of 58 adult male rats) were divided into 4 groups. The control group (group C) received no special materials except for a saline. The experimental groups were treated with 5 mL of Mediclore (group M), rosuvastatin (group R), or rosuvastatin and Mediclore (group RM), and these materials were intraperitoneally placed under the incision. At postoperative day 14, the rats underwent re-laparotomy and adhesiolysis. Three investigators blinded to group assignment scored the extent of adhesion formation, the numbers of remote adhesions, and the extent of acute/chronic inflammation, fibrosis, edema, and congestion on resected specimens via histologic examination.

Results: The macroscopic adhesion score in group RM (7.27 ± 3.51) was significantly lower than those in groups C (13.36 ± 2.24) and R (11.71 ± 1.98); group M (9.13 ± 4.09) had a significantly lower adhesion score than group C. The number of remote adhesions was significantly lower in groups R and RM than in group C. The acute inflammation score, chronic inflammation score, and fibrosis score in group RM; the acute inflammation score in group R; and the fibrosis score in group M were significantly lower than those in group C.

Conclusion: The intraperitoneal application of Mediclore and a combination of Mediclore and rosuvastatin effectively reduced postoperative adhesions.

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Mediclore®联合他汀类药物预防腹内粘连

目的:研究Mediclore®、瑞舒伐他汀及Mediclore与瑞舒伐他汀联用对大鼠黏附模型的抗黏附作用。方法:将粘连模型(58只成年雄性大鼠)分为4组。对照组(C组)除生理盐水外，不给予特殊材料。实验组分别给予5 mL Mediclore (M组)、瑞舒伐他汀(R组)或瑞舒伐他汀+ Mediclore (RM组)，并在切口下腹腔放置。术后第14天，大鼠再次开腹并进行粘连松解。三名不接受分组分配的研究人员通过组织学检查对切除标本的粘连形成程度、远处粘连数量以及急性/慢性炎症、纤维化、水肿和充血程度进行评分。结果:RM组宏观粘连评分(7.27±3.51)明显低于C组(13.36±2.24)和R组(11.71±1.98);M组(9.13±4.09)的粘连评分明显低于c组，R组和RM组的远端粘连数明显低于c组。RM组的急性炎症评分、慢性炎症评分、纤维化评分;R组急性炎症评分;M组纤维化评分明显低于c组。结论:腹腔内应用Mediclore及Mediclore联合瑞舒伐他汀可有效减少术后粘连。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.