Short-term oral rapamycin prevents age-related learning impairment in mice.

Haoyi Lei, Juan Wang, Warren Ladiges, Zhou Jiang
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Abstract

Effective treatments to prevent or delay age-related learning impairment are not generally available. In a preliminary preclinical study, mice 20 months of age were fed a diet containing 14 ppm rapamycin, an inhibitor of mTOR, for three months and then tested in a spatial navigation task. Mice fed the nonmedicated control diet showed learning impairment while mice fed the rapamycin diet were not learning impaired. This observation provides support for additional preclinical studies and suggests that short-term rapamycin treatment could be a possible strategy for preventing or delaying age-related cognitive impairment in people.

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短期口服雷帕霉素可预防小鼠与年龄相关的学习障碍。
预防或延缓与年龄有关的学习障碍的有效治疗方法尚未普遍应用。在一项初步临床前研究中,给 20 个月大的小鼠喂食含有 14 ppm 雷帕霉素(一种 mTOR 抑制剂)的食物三个月,然后进行空间导航任务测试。喂食非药物对照组饮食的小鼠表现出学习障碍,而喂食雷帕霉素饮食的小鼠则没有学习障碍。这一观察结果为更多的临床前研究提供了支持,并表明短期雷帕霉素治疗可能是预防或延缓人类与年龄相关的认知障碍的一种策略。
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