Eosinophil Cell Count Predicts Mortality in the Intensive Care Unit after Return of Spontaneous Circulation.

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Rambam Maimonides Medical Journal Pub Date : 2022-01-27 DOI:10.5041/RMMJ.10458
İlhan Korkmaz, Yusuf Kenan Tekin, Gülaçan Tekin, Erdal Demirtaş, Sefa Yurtbay, Naim Nur
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Abstract

Background: Eosinophils constitute 1%-5% of peripheral blood leukocytes, less in the presence of acute infections (referred to as eosinopenia). Studies indicate that eosinopenia can be used as a prognostic predictor for chronic obstructive pulmonary disease exacerbation, sepsis, or acute myocardial infarction disease. There are only a few studies about predicting mortality in emergency departments and intensive care units (ICUs). Prognostic studies about patients in ICUs are generally carried out using different scoring systems. We aimed to analyze if the eosinophil count can estimate the prognosis among non-traumatic patients who underwent cardiopulmonary resuscitation and were hospitalized in ICU thereafter.

Methods: The data were evaluated of 865 non-traumatic adult patients (>18 years of age) who were admitted with cardiopulmonary arrest or developed cardiopulmonary arrest during clinical follow-ups. Admission venous blood sample tests, complete blood count, and biochemical laboratory results were recorded. Arterial blood gas results were also evaluated. The mean results of the recorded laboratory results were compared between the surviving and non-surviving patients groups.

Results: There was a significant difference between the two groups in regard to platelet, eosinophil count, pH, PaO2, SaO2, and HCO3- (P<0.001 for all). In the multiple linear regression analysis, eosinophil counts were found to be an independent factor (odds ratio=0.03, 95% confidence interval 0.33-0.56, P<0.001) associated with the mortality after cardiopulmonary resuscitation.

Conclusion: Because admission eosinophil counts can be measured easily, they are inexpensive biomarkers that can be used for predicting the prognosis among the patients who have return of spontaneous circulation and are treated in ICUs.

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嗜酸性细胞计数预测重症监护病房自然循环恢复后的死亡率。
背景:嗜酸性粒细胞占外周血白细胞的1%-5%,急性感染时较少(称为嗜酸性粒细胞减少)。研究表明,红细胞减少可作为慢性阻塞性肺疾病加重、败血症或急性心肌梗死疾病的预后预测因子。关于预测急诊科和重症监护病房(icu)死亡率的研究很少。icu患者的预后研究通常采用不同的评分系统。我们的目的是分析嗜酸性粒细胞计数是否可以估计非创伤性患者的预后,这些患者接受了心肺复苏并在ICU住院。方法:对865例在临床随访中出现心肺骤停或出现心肺骤停的非创伤性成人患者(>18岁)进行资料分析。记录入院静脉血化验、全血细胞计数及生化化验结果。动脉血气结果也进行了评估。比较存活组和非存活组的平均实验室结果。结果:两组患者血小板、嗜酸性粒细胞计数、pH、PaO2、SaO2、HCO3- (p)差异有统计学意义。结论:入院时嗜酸性粒细胞计数测量简便,是一种廉价的生物标志物,可用于预测icu患者自然循环恢复后的预后。
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来源期刊
Rambam Maimonides Medical Journal
Rambam Maimonides Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
6.70%
发文量
55
审稿时长
8 weeks
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