Keratin/Polylactic acid/graphene oxide composite nanofibers for drug delivery

IF 5.3 2区 医学 Q1 PHARMACOLOGY & PHARMACY International Journal of Pharmaceutics Pub Date : 2022-07-25 DOI:10.1016/j.ijpharm.2022.121888
Gioacchino Schifino , Claudio Gasparini , Simone Drudi , Marta Giannelli , Giovanna Sotgiu , Tamara Posati , Roberto Zamboni , Emanuele Treossi , Emanuele Maccaferri , Loris Giorgini , Raffaello Mazzaro , Vittorio Morandi , Vincenzo Palermo , Monica Bertoldo , Annalisa Aluigi
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引用次数: 6

Abstract

In this work keratin/poly(lactic acid) (PLA) 50/50 wt blend nanofibers with different loadings of graphene-oxide (GO) were prepared by electrospinning and tested as delivery systems of Rhodamine Blue (RhB), selected as a model of a drug. The effect of GO on the electrospinnability and drug release mechanism and kinetics was investigated. Rheological measurements carried out on the blend solutions revealed unsatisfactory compatibility between keratin and PLA under quiet condition. Accordingly, poor interfacial adhesion between the two phases was observed by SEM analysis of a film prepared by solution casting. On the contrary, keratin chains seem to rearrange under the flux conditions of the electrospinning process thus promoting better interfacial interactions between the two polymers, thereby enhancing their miscibility, which resulted in homogeneous and defect-free nanofibers. The loading of GO into the keratin/PLA solution contributes to increase its viscosity, its shear thinning behavior, and its conductivity. Accordingly, thinner and more homogeneous nanofibers resulted from solutions with a relatively high conductivity coupled with a pronounced shear thinning behavior.

FTIR and DSC analyses have underlined, that while the PLA/GO interfacial interactions significantly compete with the PLA/keratin ones, there are no significant effects of GO on the structural organization of keratin in blend with the PLA. However, GO offers several advantages from the application point of view by slightly improving the mechanical properties of the electrospun mats and by slowing down the release of the model drug through the reduction of the matrix swelling.

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角蛋白/聚乳酸/氧化石墨烯复合纳米纤维用于药物递送
在这项工作中,角蛋白/聚乳酸(PLA) 50/50 wt共混纳米纤维与不同负载的氧化石墨烯(GO)通过静电纺丝制备,并测试作为罗丹明蓝(RhB)的递送系统,选择作为药物模型。研究了氧化石墨烯对电纺丝性能的影响以及药物释放机制和动力学。对混合溶液进行的流变学测量表明,角蛋白和聚乳酸在安静条件下的相容性不理想。因此,通过对溶液铸造制备的薄膜进行扫描电镜分析,发现两相之间的界面附着力较差。相反,角蛋白链似乎在静电纺丝过程的通量条件下重新排列,从而促进了两种聚合物之间更好的界面相互作用,从而增强了它们的混溶性,从而产生了均匀和无缺陷的纳米纤维。将氧化石墨烯加载到角蛋白/聚乳酸溶液中有助于增加其粘度、剪切变薄行为和导电性。因此,具有相对高导电性和明显剪切变薄特性的溶液产生了更薄、更均匀的纳米纤维。FTIR和DSC分析强调,尽管聚乳酸/氧化石墨烯的界面相互作用与聚乳酸/角蛋白的界面相互作用明显竞争,但氧化石墨烯对与聚乳酸共混的角蛋白的结构组织没有显著影响。然而,从应用的角度来看,氧化石墨烯提供了几个优势,通过略微改善电纺丝垫的机械性能,并通过减少基质肿胀来减缓模型药物的释放。
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来源期刊
CiteScore
10.70
自引率
8.60%
发文量
951
审稿时长
72 days
期刊介绍: The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
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