Systemic and local reactions of a water-soluble copolymer bone on a bony defect of rabbit model

Tao-Chen Lee MD , Nyuk-Kong Chang DVM , Feng-Wen Su MD , Yu-Lin Yang PhD , Thung-Ming Su MD , Yu-Jun Lin MD , Wan-Ching Lin BS , Hsiu-Yu Huang MD
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引用次数: 9

Abstract

Background

Ostene®, a synthetic water-soluble bone hemostatic agent, is commercially available. In the current study, we evaluated the systemic and local effects of this copolymer in a rabbit model.

Methods

Eighteen rabbits underwent creation of a bony defect at right iliac crest. These rabbits were then evenly divided into 3 groups. In group 1, the defect surfaces were treated with bone wax; in group 2, the defect surfaces were treated with Ostene®; in group 3, the defect surfaces were not treated with anything. Then, the animals underwent blood examinations, including WBC count, CRP, and ESR at 0, 1, 3, and 6 weeks, and were killed at 6 weeks for histologic examination. Another 6 rabbits (group 4) underwent the same surgical treatment of group 2 animals but had blood examinations of BUN and creatinine.

Results

The blood examinations showed that the WBC count, CRP, and ESR of all the animals in the first 3 groups were within normal limits in the postoperative periods. Microscopic examinations demonstrated residual bone wax and fibrotic tissue at the defect surfaces in group 1 animals. However, there was no Ostene® at the defect surfaces in group 2 animals. The groups 2 and 3 animals showed no fibrotic tissue at the defect surfaces. The group 4 animals showed normal serum levels of BUN and creatinine in the postoperative periods.

Conclusion

Ostene® is absorbable and induces no systemic inflammation (including acute renal damage) and local inflammation in animal bodies.

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水溶性共聚物骨在兔骨缺损模型上的全身和局部反应
dostene®是一种合成水溶性骨止血剂,已在市售。在目前的研究中,我们在兔模型中评估了这种共聚物的全身和局部效应。方法对18只家兔进行右髂骨骨缺损修复。将家兔平均分为3组。1组缺损面采用骨蜡处理;2组缺损表面用Ostene®处理;在第三组,缺陷表面不做任何处理。然后在0、1、3和6周对动物进行血液检查,包括WBC计数、CRP和ESR,并在6周时处死进行组织学检查。另外6只家兔(4组)接受与2组相同的手术治疗,但进行了血液BUN和肌酐检查。结果血液检查显示,前3组动物术后WBC计数、CRP、ESR均在正常范围内。显微镜检查显示,在1组动物的缺陷表面残留骨蜡和纤维化组织。然而,在2组动物的缺陷表面没有发现Ostene®。2、3组缺损表面未见纤维化组织。4组动物术后血清BUN、肌酐水平正常。结论ostene®具有可吸收性,不引起全身炎症(包括急性肾损害)和局部炎症。
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Surgical Neurology
Surgical Neurology 医学-临床神经学
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