Adverse events related to herbal dietary supplements and over-the-counter medications containing laxatives: a 10-year update from the Italian Phytovigilance and Pharmacovigilance systems.

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Annali dell'Istituto superiore di sanita Pub Date : 2022-04-01 DOI:10.4415/ANN_22_02_09

Niccolò Lombardi, Giada Crescioli, Valentina Maggini, Valentina Brilli, Francesca Menniti-Ippolito, Ilaria Ippoliti, Simona Potenza, Francesca Renda, Gabriela Mazzanti, Annabella Vitalone, Alfredo Vannacci, Fabio Firenzuoli

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引用次数: 2

Abstract

Introduction: Products containing anthraquinones (AQ) are associated with an increased risk of serious adverse events (AEs). We performed an update of the available evidence retrieved by the spontaneous reports of AE associated with herbal dietary supplement (DS) and over-the-counter medications (OTC-M) used as laxatives.

Methods: Analysis and evaluation of AE reports retrieved from the Italian Phytovigilance and Pharmacovigilance systems was performed from February 2011 to December 2020.

Results: Totally 110 AE reports, 24 related to herbal DS and 86 to OTC-M, were analyzed. Most subjects were females. Herbal products analyzed mostly contained AQ derivatives. Most AEs were gastrointestinal (41.6%), central nervous system (18.2%), and dermatological disorders (12.6%).

Conclusions: The number of AE reports recorded in the last 10 years is still relatively low. However, given the seriousness of some AEs, that does not represent a guarantee of safety. This study may contribute to enhance public awareness on the risks associated with misuse or abuse of laxatives.

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与含泻药的草药膳食补充剂和非处方药相关的不良事件:意大利植物警戒和药物警戒系统的10年更新

含有蒽醌(AQ)的产品与严重不良事件(ae)的风险增加相关。我们更新了与草药膳食补充剂(DS)和非处方药(OTC-M)作为泻药相关的AE自发报告的现有证据。方法:对2011年2月至2020年12月从意大利植物警戒和药物警戒系统中检索到的AE报告进行分析和评价。结果:共分析AE报告110份，其中中药DS 24份，非处方中药86份。大多数研究对象为女性。分析的草药产品主要含有AQ衍生物。ae以胃肠道(41.6%)、中枢神经系统(18.2%)和皮肤病(12.6%)为主。结论:近10年的AE报告数量仍然相对较少。然而，考虑到一些ae的严重性，这并不代表安全的保证。本研究可能有助于提高公众对误用或滥用泻药风险的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annali dell'Istituto superiore di sanita PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews. The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office. The journal is in English.