Diagnostic frequency, response to therapy, and long-term prognosis among horses and ponies with pituitary par intermedia dysfunction, 1993-2004.

IF 2.6 2区 农林科学 Journal of Veterinary Internal Medicine Pub Date : 2012-07-01 Epub Date: 2012-04-24 DOI:10.1111/j.1939-1676.2012.00932.x
B W Rohrbach, J R Stafford, R S W Clermont, S M Reed, H C Schott, F M Andrews
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引用次数: 35

Abstract

Background: Pituitary pars intermedia dysfunction (PPID) is common in older horses.

Objectives: To determine diagnosis frequency, prognostic factors, long-term survival, and owner satisfaction with treatment.

Animals: Medical records from horses diagnosed with PPID, 1993-2004.

Methods: A retrospective cohort design with data collected from the Veterinary Medical Data Base (VMDB) and a cohort of 3 VTHs. Proportional accessions, annual incidence, and demographics were compared for all accessions. During the same period, a subset of medical records (n = 44) was extracted and owners (n = 34) contacted to obtain long-term follow-up information.

Results: Diagnoses of PPID were reported for 217 horses that presented to VTHs and were reported to the VMDB. Proportional diagnosis increased from 0.25/1,000 in 1993 to 3.72/1,000 in 2002. For 44 horses included in the follow-up study, the most commons signs were hirsutism (84%) and laminitis (50%). Of 34 horse owners contacted, the average time from onset of signs to diagnosis was 180 days. Improvement in ≥ 1 signs, 2 months after diagnosis, was reported by 9/22 (41%) of horse owners. Clinical signs and clinicopathologic data were not associated with survival, and 50% of horses were alive 4.6 years after diagnosis. Cause of death among horses (15/20; 85%) was euthanasia, and 11/15 (73%) were euthanized because of conditions associated with PPID. Most horse owners (28/29; 97%) said they would treat a second horse for PPID.

Conclusion and clinical importance: PPID was diagnosed with increasing frequency, and 50% of horses survived 4.5 years after diagnosis. Owners were satisfied with their horses' quality of life and would treat a second horse if diagnosed.

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1993-2004年马和矮马垂体中叶功能障碍的诊断频率、治疗反应和长期预后。
背景:垂体部中间功能障碍(PPID)在老年马中很常见。目的:确定诊断频率、预后因素、长期生存率和患者对治疗的满意度。动物:1993-2004年诊断为PPID的马的医疗记录。方法:采用回顾性队列设计,数据来自兽医数据库(VMDB)和3个vth队列。比较了所有病例的比例、年发病率和人口统计数据。在同一时期,提取了一部分医疗记录(n = 44),并联系了所有者(n = 34),以获得长期随访信息。结果:报告了217匹出现VTHs并报告给VMDB的马的PPID诊断。比例诊断率由1993年的0.25/ 1000上升到2002年的3.72/ 1000。在随访研究的44匹马中,最常见的症状是多毛症(84%)和足部炎(50%)。在联系的34名马主中,从出现症状到诊断的平均时间为180天。9/22(41%)的马主报告在诊断后2个月出现≥1个症状的改善。临床体征和临床病理数据与生存率无关,50%的马在诊断后存活4.6年。马的死亡原因(15/20;85%)为安乐死,11/15(73%)因与PPID相关的条件而被安乐死。大多数马主(28/29;97%)表示他们会为第二匹马治疗PPID。结论及临床意义:PPID的诊断频率越来越高,50%的马在诊断后存活了4.5年。马主对马的生活质量很满意,如果被诊断出患有此病,他们会治疗第二匹马。
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来源期刊
Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine Veterinary-General Veterinary
自引率
11.50%
发文量
243
期刊介绍: The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.
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