{"title":"Lipase activity in lipidomics - a hidden problem?","authors":"Samuel Furse, J Antoinette Killian","doi":"10.3109/09687688.2013.835125","DOIUrl":null,"url":null,"abstract":"A perennial problem in ‘omics’ studies, is ensuring that the molecular profile produced is a true representation of that in the system from which it comes. Scientists working in the field of proteomics, still the most advanced ‘omics’ discipline, have for some time recognized the potential of proteases to interfere with the results they obtain (Lopez-Otin and Overall 2002). This remains prescient with the advent of quantitative proteomics. It comes as no surprise, therefore, that protease inhibitors have been standard in proteomics research for some years and that for much of this time, convenient catch-all small-molecule inhibitor packages have been commercially available.","PeriodicalId":18858,"journal":{"name":"Molecular Membrane Biology","volume":" ","pages":"347-9"},"PeriodicalIF":0.0000,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/09687688.2013.835125","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Membrane Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/09687688.2013.835125","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/9/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 4
Abstract
A perennial problem in ‘omics’ studies, is ensuring that the molecular profile produced is a true representation of that in the system from which it comes. Scientists working in the field of proteomics, still the most advanced ‘omics’ discipline, have for some time recognized the potential of proteases to interfere with the results they obtain (Lopez-Otin and Overall 2002). This remains prescient with the advent of quantitative proteomics. It comes as no surprise, therefore, that protease inhibitors have been standard in proteomics research for some years and that for much of this time, convenient catch-all small-molecule inhibitor packages have been commercially available.
期刊介绍：
Cessation.
Molecular Membrane Biology provides a forum for high quality research that serves to advance knowledge in molecular aspects of biological membrane structure and function. The journal welcomes submissions of original research papers and reviews in the following areas:
• Membrane receptors and signalling
• Membrane transporters, pores and channels
• Synthesis and structure of membrane proteins
• Membrane translocation and targeting
• Lipid organisation and asymmetry
• Model membranes
• Membrane trafficking
• Cytoskeletal and extracellular membrane interactions
• Cell adhesion and intercellular interactions
• Molecular dynamics and molecular modelling of membranes.
• Antimicrobial peptides.
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