Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents.

Q2 Pharmacology, Toxicology and Pharmaceutics Drug metabolism and personalized therapy Pub Date : 2022-06-24 DOI:10.1515/dmpt-2021-0115

Murtala Akanji Abdullahi, Elijah Oladapo Oyinloye, Akinyinka Alabi, Aderonke Adeyinka Aderinola, Luqman Opeyemi Ogunjimi, Adesina A Omoloye, Ayobami A Odusote, Joseph O Olusola, Oluwatosin O Adebayo, Wasiu Eniola Olooto

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Abstract

Objectives: Several studies have established the ethnobotanical benefits of Pupalia lappacea (PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract of P. lappacea in rodents was carried out in this study.

Methods: Different groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days. The control group received distilled water (10 mL/kg). After 90 days, some rats were left for additional 30 days without treatment for reversibility study. Blood and organs samples were collected for different evaluations at the end of study periods.

Results: The extract decreased the bodyweights, feeding and water intakes in female rats. PL increased the weights of the liver and kidney in male rats. PL increased the red blood cell (RBC), packed cell volume (PCV), hemoglobin (Hb), triglycerides (TRIG), cholesterol and high density lipoprotein (HDL) contents in rats. PL (250 mg/kg) significantly reduced the sperm motility and serum testosterone level. Cyto-architectural distortions of the testes, liver and spleen were visible.

Conclusions: The findings showed that P. lappacea is relatively safe at lower doses but cautions should be taken at higher dose.

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水乙醇提取物的毒理学评价汁液。(苋科)啮齿类动物。

目的:几项研究在没有对其安全性进行广泛毒理学评估的情况下，已经在实验动物中建立了Pupalia lappacea (PL)的民族植物学益处。因此，本研究在啮齿类动物中进行了广泛的亚慢性口服水乙醇叶提取物的毒理学研究。方法:按10、50、250 mg/kg剂量给予不同组大鼠，连续90 d。对照组给予蒸馏水(10 mL/kg)。90天后，部分大鼠再留30天不给药，进行可逆性研究。在研究结束时收集血液和器官样本进行不同的评估。结果:黄芪提取物能显著降低雌性大鼠体重、摄食量和饮水量。PL增加了雄性大鼠肝脏和肾脏的重量。PL增加了大鼠红细胞(RBC)、堆积细胞体积(PCV)、血红蛋白(Hb)、甘油三酯(TRIG)、胆固醇和高密度脂蛋白(HDL)含量。PL (250 mg/kg)显著降低精子活力和血清睾酮水平。可见睾丸、肝脏和脾脏的细胞结构扭曲。结论:小檗在低剂量时相对安全，但在高剂量时需注意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug metabolism and personalized therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

2.30

自引率

0.00%

发文量

期刊介绍： Drug Metabolism and Personalized Therapy (DMPT) is a peer-reviewed journal, and is abstracted/indexed in relevant major Abstracting Services. It provides up-to-date research articles, reviews and opinion papers in the wide field of drug metabolism research, covering established, new and potential drugs, environmentally toxic chemicals, the mechanisms by which drugs may interact with each other and with biological systems, and the pharmacological and toxicological consequences of these interactions and drug metabolism and excretion. Topics: drug metabolizing enzymes, pharmacogenetics and pharmacogenomics, biochemical pharmacology, molecular pathology, clinical pharmacology, pharmacokinetics and drug-drug interactions, immunopharmacology, neuropsychopharmacology.