First detection of SARS-CoV-2 lineage A.27 in Sardinia, Italy.

IF 1.7 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Annali dell'Istituto superiore di sanita Pub Date : 2022-01-01 DOI:10.4415/ANN_22_01_01

Alessandra Lo Presti, Ferdinando Coghe, Angela Di Martino, Sara Fais, Riccardo Cappai, Manuela Marra, Maria Carollo, Marco Crescenzi, Germano Orrù, Giovanni Rezza, Paola Stefanelli

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引用次数: 2

Abstract

Introduction: Multiple variants of SARS-CoV-2, since the end of 2020 have emerged in many geographical areas and are currently under surveillance worldwide highlighting the continuing need for genomic monitoring to detect variants previously not yet identified.

Methods: In this study, we used whole-genome sequencing (WGS) and phylogenetic analysis to investigate A.27 lineage SARS-CoV-2 from Sardinia, Italy.

Results: The Italian A.27 lineage genomes from Sardinia appeared related in a clade with genomes from France. Among the key mutations identified in the spike protein, the N501Y and the L452R deserve attention as considered likely vaccine escape mutations. Additional mutations were also here reported.

Conclusion: A combination of features could explain our data such as SARS-CoV-2 genetic variability, viral dynamics, the human genetic diversity of Sardinian populations, the island context probably subjected to different selective pressures. Molecular and genomic investigation is essential to promptly identify variants with specific mutations with potential impact on public health and vaccine formulation.

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意大利撒丁岛首次发现SARS-CoV-2 A.27谱系。

自2020年底以来，在许多地理区域出现了SARS-CoV-2的多种变体，目前正在全球范围内进行监测，这突出表明继续需要进行基因组监测，以发现以前尚未发现的变体。方法:采用全基因组测序(WGS)和系统发育分析方法对来自意大利撒丁岛的A.27谱系SARS-CoV-2进行研究。结果:来自撒丁岛的意大利a .27谱系基因组与来自法国的基因组有亲缘关系。在刺突蛋白中发现的关键突变中，N501Y和L452R被认为可能是疫苗逃逸突变，值得关注。这里还报道了其他突变。结论:SARS-CoV-2的遗传变异性、病毒动力学、撒丁岛人群的人类遗传多样性、岛屿环境可能受到不同的选择压力等特征的组合可以解释我们的数据。分子和基因组调查对于迅速确定具有对公共卫生和疫苗配制有潜在影响的特定突变的变异至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annali dell'Istituto superiore di sanita PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews. The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office. The journal is in English.