A potential serological biomarker for inner ear pathologies: OTOLIN-1.

IF 2.1 4区医学 Q2 OTORHINOLARYNGOLOGY Acta Otorhinolaryngologica Italica Pub Date : 2022-08-01 DOI:10.14639/0392-100X-N2074

Emilio Avallone, Heike Schmitt, Giorgio Lilli, Athanasia Warnecke, Anke Lesinski-Schiedat, Thomas Lenarz, Kerstin Willenborg

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引用次数: 1

Abstract

Objective: The goal of the study was to determine whether the level of OTOLIN-1, a protein whose expression is highly restricted to the inner ear,is increased in the body fluids of patients with inner ear disorders in comparison to healthy subjects.

Methods: In the preliminary part of the study, OTOLIN-1 levels were measured in the serum, urine, and saliva of patients with an acute onset of Ménière´s disease and in healthy individuals. Subsequently, only serum OTOLIN-1 levels were taken into account and were compared between patients with acute onset of Ménière´s disease, sudden hearing loss, vestibular neuritis and healthy subjects.

Results: The most reliable diagnostic parameter was OTOLIN-1 levels in serum. Serum samples of patients with Ménière's disease and sudden hearing loss showed significantly higher OTOLIN-1 levels than those from healthy individuals. In addition, there was no significant difference between the serum concentration of OTOLIN-1 in patients with vestibular neuritis and the control group.

Conclusions: Serum levels of OTOLIN-1 can potentially be used as a biomarker for acute onset of inner ear disorders due to its significant increase in patients with acute Meniere´s disease and sudden hearing loss in comparison to healthy individuals.

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潜在的内耳病理血清学生物标志物:OTOLIN-1。

目的:本研究的目的是确定与健康受试者相比，内耳疾病患者体液中的OTOLIN-1(一种高度局限于内耳表达的蛋白质)水平是否升高。方法:在研究的初步阶段，测量了急性mims患者和健康个体的血清、尿液和唾液中的OTOLIN-1水平。随后，只考虑血清OTOLIN-1水平，并比较急性起病的mims疾病、突发性听力损失、前庭神经炎患者和健康受试者之间的水平。结果:血清OTOLIN-1水平是最可靠的诊断指标。与健康个体相比，患有membroinitre病和突发性听力损失的患者的血清样本显示OTOLIN-1水平显著升高。此外，前庭神经炎患者血清OTOLIN-1浓度与对照组无显著差异。结论:血清OTOLIN-1水平可能被用作内耳疾病急性发作的生物标志物，因为与健康个体相比，急性梅尼埃病和突发性听力损失患者的血清OTOLIN-1水平显著增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Otorhinolaryngologica Italica OTORHINOLARYNGOLOGY-

CiteScore

3.40

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Otorhinolaryngologica Italica first appeared as “Annali di Laringologia Otologia e Faringologia” and was founded in 1901 by Giulio Masini. It is the official publication of the Italian Hospital Otology Association (A.O.O.I.) and, since 1976, also of the Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale (S.I.O.Ch.C.-F.). The journal publishes original articles (clinical trials, cohort studies, case-control studies, cross-sectional surveys, and diagnostic test assessments) of interest in the field of otorhinolaryngology as well as clinical techniques and technology (a short report of unique or original methods for surgical techniques, medical management or new devices or technology), editorials (including editorial guests – special contribution) and letters to the Editor-in-Chief. Articles concerning science investigations and well prepared systematic reviews (including meta-analyses) on themes related to basic science, clinical otorhinolaryngology and head and neck surgery have high priority.