Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-09-01 DOI:10.1080/10641963.2022.2110258

Yushan Li, Yuanyuan Wei, Jiong Shao

引用次数: 0

Abstract

Objectives: This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP).

Methods: Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated.

Results: Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529.

Conclusion: Serum miR-101 level may be a biomarker for grading HDCP.

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妊娠并发高血压疾病患者血液和尿液中 miR-101 水平的诊断价值。

研究目的本研究探讨了 miR-101 在妊娠期高血压并发症（HDCP）中的临床意义：方法：纳入妊娠高血压（GH）/轻度子痫前期（mPE）/重度子痫前期（sPE）孕妇。测量miR-101水平。评估了miR-101与可溶性类酪氨酸激酶-1（sFlt-1）之间的相关性、miR-101的预测价值以及影响HDCP分级的因素：血清 miR-101 下调，并与 sFlt-1 呈负相关。miR-101 是 HDCP 的独立危险因素，并随 HDCP 严重程度而降低。在区分 GH 和 mPE 以及 mPE 和 sPE 时，miR-101 的曲线下面积分别为 0.7764 和 0.8529：结论：血清 miR-101 水平可能是分级 HDCP 的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.