The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

IF 2.1 4区医学 Q3 RESPIRATORY SYSTEM Canadian respiratory journal Pub Date : 2022-08-23 eCollection Date: 2022-01-01 DOI:10.1155/2022/6810745

Desheng Sun, Rong Lin, Yao Ouyang

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Abstract

Objective: The aim of the study was to explore the relevance of CD40, CD86, and GSTO1 with the pathogenesis of COPD.

Methods: Patients with acute exacerbation of COPD were contrasted with the healthy and nonsmoking ones and smoking but without COPD ones. The changes of CD40, CD86, and GSTO1 in the peripheral blood, collected from different groups, were detected by flow cytometry and western blotting, respectively.

Results: Compared with the nonsmoking group and smoking but without the COPD group, the expression of CD40 and CD86 of the patients with COPD increased significantly, but the expression of GSTO1 decreased. CD40 and CD86 were negatively correlated with FEV1%, while GSTO1 was positively correlated with FEV1% and negatively correlated with CD40 and CD86.

Conclusion: CD40, CD86, and GSTO1 may play a role in the pathogenesis of COPD, and they are related to the severity of COPD and the degree of changes in the lung function.

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CD40、CD86和谷胱甘肽s -转移酶Omega - 1在慢性阻塞性肺疾病发病机制中的作用

目的:探讨CD40、CD86、GSTO1与COPD发病机制的相关性。方法:将慢性阻塞性肺病急性加重期患者与健康非吸烟组、吸烟非COPD组进行对比分析。采用流式细胞术和western blotting分别检测各组大鼠外周血CD40、CD86和GSTO1的变化。结果:与非吸烟组和吸烟未伴COPD组比较，COPD患者CD40、CD86表达明显升高，GSTO1表达降低。CD40、CD86与FEV1%呈负相关，GSTO1与FEV1%呈正相关，与CD40、CD86呈负相关。结论:CD40、CD86、GSTO1可能在COPD的发病机制中发挥作用，且与COPD的严重程度及肺功能改变程度有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian respiratory journal 医学-呼吸系统

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.