Investigation on how dynamic effective connectivity patterns encode the fluctuating pain intensity in chronic migraine

Q2 Medicine Neurobiology of Pain Pub Date : 2022-08-01 DOI:10.1016/j.ynpai.2022.100100
Iege Bassez , Frederik Van de Steen , Sophie Hackl , Pauline Jahn , Astrid Mayr , Daniele Marinazzo , Enrico Schulz
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Abstract

Chronic migraine is characterised by persistent headaches for >15 days per month; the intensity of the pain is fluctuating over time. Here, we explored the dynamic interplay of connectivity patterns between regions known to be related to pain processing and their relation to the ongoing dynamic pain experience. We recorded EEG from 80 sessions (20 chronic migraine patients in 4 separate sessions of 25 min). The patients were asked to continuously rate the intensity of their endogenous headache. On different time-windows, a dynamic causal model (DCM) of cross spectral responses was inverted to estimate connectivity strengths. For each patient and session, the evolving dynamics of effective connectivity were related to pain intensities and to pain intensity changes by using a Bayesian linear model. Hierarchical Bayesian modelling was further used to examine which connectivity-pain relations are consistent across sessions and across patients.

The results reflect the multi-facetted clinical picture of the disease. Across all sessions, each patient with chronic migraine exhibited a distinct pattern of pain intensity-related cortical connectivity. The diversity of the individual findings are accompanied by inconsistent relations between the connectivity parameters and pain intensity or pain intensity changes at group level. This suggests a rejection of the idea of a common neuronal core problem for chronic migraine.

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动态有效连接模式如何编码慢性偏头痛波动疼痛强度的研究
慢性偏头痛的特点是每月持续头痛15天;疼痛的强度随时间而波动。在这里,我们探索了与疼痛处理相关的区域之间的连接模式的动态相互作用,以及它们与正在进行的动态疼痛体验的关系。我们记录了80组的脑电图(20例慢性偏头痛患者分为4组,每组25分钟)。这些患者被要求连续评估他们的内源性头痛的强度。在不同的时间窗下,反演了交叉光谱响应的动态因果模型(DCM)来估计连通性强度。通过贝叶斯线性模型,对每个患者和每个疗程,有效连通性的演变动态与疼痛强度和疼痛强度变化相关。层次贝叶斯模型进一步用于检查连接-疼痛关系在不同疗程和不同患者之间是一致的。结果反映了该病的多面临床情况。在所有的治疗过程中,每个慢性偏头痛患者都表现出与疼痛强度相关的皮层连接的独特模式。个体研究结果的多样性伴随着连通性参数与疼痛强度或疼痛强度变化在群体水平上的不一致关系。这表明对慢性偏头痛有共同的神经元核心问题的观点的拒绝。
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来源期刊
Neurobiology of Pain
Neurobiology of Pain Medicine-Anesthesiology and Pain Medicine
CiteScore
4.40
自引率
0.00%
发文量
29
审稿时长
54 days
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