Connecting chemical exposome to human health using high-resolution mass spectrometry-based biomonitoring: Recent advances and future perspectives

IF 6.9 2区化学 Q1 SPECTROSCOPY Mass Spectrometry Reviews Pub Date : 2022-09-05 DOI:10.1002/mas.21805

Yuan-Chih Chen, Jing-Fang Hsu, Chih-Wei Chang, Shih-Wen Li, Ya-Chi Yang, Mu-Rong Chao, Hauh-Jyun C. Chen, Pao-Chi Liao

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引用次数: 5

Abstract

Compared with the rapid advances in genomics leading to broad understanding of human disease, the linkage between chemical exposome and diseases is still under investigation. High-resolution mass spectrometry (HRMS) is expected to accelerate the process via relatively accurate and precise biomonitoring of human exposome. This review covers recent advancements in biomonitoring of exposed environmental chemicals (chemical exposome) using HRMS described in the 124 articles that resulted from a systematic literature search on Medline and Web of Science databases. The analytical strategic aspects, including the selection of specimens, sample preparation, instrumentation, untargeted versus targeted analysis, and workflows for MS-based biomonitoring to explore the environmental chemical space of human exposome, are deliberated. Applications of HRMS in human exposome investigation are presented by biomonitoring (1) exposed chemical compounds and their biotransformation products; (2) DNA/protein adducts; and (3) endogenous compound perturbations. Challenges and future perspectives are also discussed.

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使用基于高分辨率质谱的生物监测将化学暴露与人类健康联系起来：最新进展和未来展望

与基因组学的快速发展导致对人类疾病的广泛理解相比，化学暴露与疾病之间的联系仍在研究中。高分辨率质谱（HRMS）有望通过相对准确和精确的人体暴露生物监测来加速这一过程。这篇综述涵盖了在Medline和Web of Science数据库上系统检索文献后发表的124篇文章中描述的使用HRMS对暴露的环境化学品（化学暴露组）进行生物监测的最新进展。讨论了分析战略方面，包括样本的选择、样本制备、仪器、非靶向分析与靶向分析，以及基于MS的生物监测工作流程，以探索人类暴露的环境化学空间。通过生物监测，介绍了HRMS在人体暴露研究中的应用：（1）暴露的化合物及其生物转化产物；（2） DNA/蛋白质加合物；和（3）内源性化合物扰动。还讨论了挑战和未来前景。

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来源期刊

Mass Spectrometry Reviews 物理-光谱学

CiteScore

16.30

自引率

3.00%

发文量

期刊介绍： The aim of the journal Mass Spectrometry Reviews is to publish well-written reviews in selected topics in the various sub-fields of mass spectrometry as a means to summarize the research that has been performed in that area, to focus attention of other researchers, to critically review the published material, and to stimulate further research in that area. The scope of the published reviews include, but are not limited to topics, such as theoretical treatments, instrumental design, ionization methods, analyzers, detectors, application to the qualitative and quantitative analysis of various compounds or elements, basic ion chemistry and structure studies, ion energetic studies, and studies on biomolecules, polymers, etc.