The role of PET/CT in connective tissue disorders: systemic sclerosis, Sjögren's syndrome and systemic lupus erythematosus.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... Pub Date : 2022-09-01 DOI:10.23736/S1824-4785.22.03463-X

Andrea Guarneri, Elisabetta Perrone, Silvia L Bosello, Maria A D'Agostino, Lucia Leccisotti

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Abstract

Advanced imaging techniques are needed to help clinicians in the diagnosis, in the choice of the right time for therapeutic interventions or for modifications and monitoring of treatment response in patients with autoimmune connective tissue diseases. Nuclear medicine imaging, especially PET/CT and PET/MRI, may play an important role in detecting disease activity, assessing early treatment response as well as in clarifying the complex mechanisms underlying systemic sclerosis, Sjögren's syndrome or systemic lupus erythematosus. In addition, [¹⁸F]FDG PET/CT may help in excluding or detecting coexisting malignancies. Other more specific radiopharmaceuticals are being developed and investigated, targeting specific cells and molecules involved in connective tissue diseases. Further larger studies with standardized imaging protocol and image interpretation are strongly required before including PET/CT in the diagnostic work-up of subsets of patients with autoimmune connective tissue diseases.

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PET/CT在结缔组织疾病中的作用:系统性硬化症，Sjögren综合征和系统性红斑狼疮。

需要先进的成像技术来帮助临床医生在自身免疫性结缔组织疾病患者的诊断，选择正确的治疗干预时间或修改和监测治疗反应。核医学成像，特别是PET/CT和PET/MRI，可能在检测疾病活动性、评估早期治疗反应以及阐明系统性硬化症、Sjögren综合征或系统性红斑狼疮的复杂机制方面发挥重要作用。此外，[18F]FDG PET/CT可能有助于排除或发现共存的恶性肿瘤。其他更具体的放射性药物正在开发和研究中，目标是与结缔组织疾病有关的特定细胞和分子。在将PET/CT纳入自身免疫性结缔组织疾病患者亚群的诊断工作之前，强烈需要进一步进行具有标准化成像方案和图像解释的更大规模研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

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