The Association Between Qtc, Qtd, TPE, And Fragmented QRS Before And After PPCI With Hospital Mortality In STEMI Patients.

Q2 Medicine Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2022-01-01 DOI:10.2174/1871529X22666220926125709

Mohammad Hassan Namazi, Ayoub Salehi, Mohammad Ali Akbarzadeh, Saeed Alipour Parsa, Morteza Safi, Hossein Vakili, Habibollah Saadat, Vahid Eslami, Farshid Heidarpour Kiaee, Saeed Nourian, Nasim Sohrabifar, Isa Khaheshi

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Abstract

Background: ST-elevation myocardial infarction (STEMI) is known to be associated with significant arrhythmia and consequent mortality. QT prolongation is a risk factor for arrhythmia in STEMI patients who underwent primary percutaneous coronary intervention (PPCI). The aim of this investigation was to evaluate the association of corrected QT interval (QTc), QT dispersion (QTd), T-wave peak to end (TPE), and fragmented QRS with mortality in these patients.

Methods: Eligible patients with the characteristic symptoms of STEMI who underwent PPCI were included. QTc, QTd, TPE, and fragmented QRS were measured before and after the PPCI. These predictors were compared between patients who died during hospitalization and discharged patients.

Results: After coronary angiography, 10 patients (4%) died during the hospitalization after PPCI. Comparing the non-survivers and discharged patients in terms of arrhythmia predictors showed that the mean QT dispersion and TPE before intervention were significantly higher in the non-survivors. Also, the number of patients who experienced fragmented QRS before and after the intervention was significantly higher in the non-survivors.

Conclusion: These data suggested that evaluating such arrhythmia predictors, especially before PPCI, could be used as a predictor of mortality in STEMI patients who underwent PPCI.

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冠状动脉造影术（PPCI）前后 QTc、QTd、TPE 和 QRS 分段与 STEMI 患者住院死亡率的关系。

导言：众所周知，ST 段抬高型心肌梗死（STEMI）与严重心律失常及由此导致的死亡率有关。在接受经皮冠状动脉介入治疗（PPCI）的 STEMI 患者中，QT 间期延长是导致心律失常的一个危险因素。本研究旨在评估校正 QT 间期（QTc）、QT 离散度（QTd）、T 波峰端（TPE）和 QRS 波断与这些患者死亡率的关系：纳入具有 STEMI 特征性症状并接受了 PPCI 的合格患者。PPCI前后测量了QTc、QTd、TPE和QRS片段。这些预测指标在住院期间死亡的患者和出院患者之间进行了比较：冠状动脉造影术后，有10名患者（4%）在PPCI术后住院期间死亡。比较非存活患者和出院患者的心律失常预测指标发现，非存活患者干预前的平均 QT 离散度和 TPE 明显更高。此外，非存活患者在干预前后出现 QRS 分裂的人数也明显较多：这些数据表明，评估此类心律失常预测指标，尤其是在进行 PPCI 之前，可作为接受 PPCI 的 STEMI 患者的死亡率预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

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期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.