The Correlation Between Copeptin and Volume Status in Chronic Hemodialysis Patients.

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY Iranian journal of kidney diseases Pub Date : 2022-09-01

Negar Sheikh Davoodi, Farzanehsadat Minoo

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引用次数: 0

Abstract

Introduction: Currently There is no noninvasive chemical biomarker, available for evaluating volume status, in individuals with endstage kidney disease (ESKD). This study aimed to determine the relationship between copeptin level and volume status in hemodialysis patients.

Methods: This clinical trial enrolled 84 patients with ESKD (Mean age ± SD: 54.31 ± 15.47) on maintenance hemodialysis (3-times weekly, 4h /session). Plasma levels of Hb, copeptin, HCT, Na, and BUN, patients' weight, systolic and diastolic blood pressure and mean arterial pressure were measured, before and after hemodialysis. Age, sex, etiology of kidney failure, and duration of dialysis were also recorded., and the correlation between copeptin level and all variables was evaluated.

Results: There was a significant positive correlation between copeptin level and Hb (r = 0.313, P < .05), and HCT (r = 0.25, P < .05), while a negative association was found between copeptin level and Na (r = -0.051, P > .05) and IDWG (r = -0.05, P > .05). Although copeptin concentration was higher in females before (929.23 pmol/L) and after dialysis (783.3 pmol/L) than male patients (657.05 and 697.45 pmol/L), the mean copeptin changes was higher in male (205 pmol/L) than female (197 pmol/L) (P > .05). The level of copeptin decreased (P > .05) but the level of Hb (P < .05), HCT (P < .05), and Na (P > .05) were increased after dialysis compared to pre-dialysis period.

Conclusions: Copeptin could be used as a surrogate marker for the diagnosis of volume status in hemodialysis patients. DOI: 10.52547/ijkd.7119.

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慢性血液透析患者Copeptin与容量状态的相关性研究。

目前，尚无无创化学生物标志物可用于评估终末期肾病(ESKD)患者的容量状态。本研究旨在确定血透患者copeptin水平与血容量状态的关系。方法:本临床试验纳入84例ESKD患者(平均年龄±SD: 54.31±15.47)，进行维持性血液透析(每周3次，每次4小时)。测定血液透析前后血浆Hb、copeptin、HCT、Na、BUN水平、患者体重、收缩压、舒张压及平均动脉压。年龄、性别、肾功能衰竭的病因和透析持续时间也被记录下来。，并评价copeptin水平与各变量的相关性。结果:copeptin水平与Hb (r = 0.313, P < 0.05)、HCT (r = 0.25, P < 0.05)呈正相关，与Na (r = -0.051, P > 0.05)、IDWG (r = -0.05, P > 0.05)呈负相关。女性患者透析前和透析后copeptin浓度分别为929.23 pmol/L和783.3 pmol/L，高于男性患者(657.05和697.45 pmol/L)，但男性患者copeptin平均变化(205 pmol/L)高于女性患者(197 pmol/L) (P > 0.05)。与透析前相比，透析后血清copeptin水平降低(P > 0.05)， Hb (P < 0.05)、HCT (P < 0.05)、Na (P > 0.05)水平升高。结论:Copeptin可作为血液透析患者血容量状态的替代指标。DOI: 10.52547 / ijkd.7119。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.