{"title":"Antidepressant alkaloids from the rhizomes of <i>Corydalis decumbens</i>.","authors":"Qin-Ge Ma, Ye Tang, Mao-Hua He, Rong-Rui Wei","doi":"10.1515/znc-2021-0108","DOIUrl":null,"url":null,"abstract":"<p><p>Two new alkaloids (<b>1</b> and <b>2</b>), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole (<b>1</b>) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione (<b>2</b>), along with thirteen known alkaloids (<b>3</b>-<b>15</b>) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl<sub>3</sub> extraction of <i>Corydalis decumbens</i> for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (<b>1</b>-<b>15</b>) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake <i>in vitro</i>. Among them, compounds <b>1</b>, <b>2</b>, <b>4</b>, and <b>6</b> showed certain antidepressant activities.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1515/znc-2021-0108","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/25 0:00:00","PubModel":"Print","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Two new alkaloids (1 and 2), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole (1) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione (2), along with thirteen known alkaloids (3-15) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl3 extraction of Corydalis decumbens for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (1-15) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake in vitro. Among them, compounds 1, 2, 4, and 6 showed certain antidepressant activities.
期刊介绍：
A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.
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